Evidence map›Paper›PMID 24632669›Full record

ReviewThe Pediatric infectious disease journal2014

Progressive multifocal leukoencephalopathy in pediatric patients: case report and literature review.

Hayden Schwenk, Lynn Ramirez-Avila, Shu-Hsien Sheu, Christian Wuthrich, Jeff Waugh, Adam Was, Umberto Degirolami, Sandra Burchett, Igor J Koralnik, Asim Ahmed

Abstract readCase ReportsReview
In one paragraph

Review in The Pediatric infectious disease journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Hayden SchwenkFrom the *Department of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA; †Division of Infectious Diseases, Boston Children's Hospital, Boston, MA; ‡Division of Pediatric Infectious Diseases, David Geffen School of Medicine at UCLA, Mattel Children's Hospital, Los Angeles, CA; §Department of Pathology, Brigham and Women's Hospital; ¶Department of Neurology, Beth Israel Deaconess Medical Center; ‖Department of Neurology, Boston Children's Hospital, Boston, MA; **Department of Pediatrics, Stanford University School of Medicine, Stanford, CA; ††Department of Pathology, Boston Children's Hospital, Boston, MA.
Lynn Ramirez-Avila
Shu-Hsien Sheu
Christian Wuthrich
Jeff Waugh
Adam Was
Umberto Degirolami
Sandra Burchett
Igor J Koralnik
Asim Ahmed
Boston Children's Hospital · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USStanford University · US

Funding

PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Role of Inflammation in Progressive Multifocal LeukoencephalopathyR01NS047029 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2004 to 2018
$6.4M
Pediatric Infectious Diseases Research TrainingT32HD055148 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI WESSELS, MICHAEL R · 2008 to 2018
$2.7M
Pathogenesis of a JC Virus Variant in Pyramidal NeuronsR01NS074995 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2012 to 2016
$1.8M
Expanding training in comparative effectiveness for child health researchersT32HS019485 · AHRQ · BOSTON CHILDREN'S HOSPITAL · PI FINKELSTEIN, JONATHAN A · 2010 to 2010
$825k
Translational applications of Progressive Multifocal Leukoencephalopathy studiesK24NS060950 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KORALNIK, IGOR J. · 2008 to 2012
$707k
Cellular Immunity to JC Virus in AIDS-Associated Progressive Multifocal LeukoenceR56NS041198 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KORALNIK, IGOR J. · 2010 to 2010
$435k
AHRQ HHS T32 HS019485AHRQ HHS T32 HS 019485-01NIAID NIH HHS T32 AI 007433NIAID NIH HHS T32 AI007433NICHD NIH HHS T32 HD055148NICHD NIH HHS T32 HD 055148-02NINDS NIH HHS K24 NS 060950NINDS NIH HHS K24 NS060950NINDS NIH HHS R01 NS 047029NINDS NIH HHS R01 NS047029NINDS NIH HHS R01 NS 074995NINDS NIH HHS R01 NS074995NINDS NIH HHS R56 NS 041198NINDS NIH HHS R56 NS041198
6 · The paper itself

Abstract

Progressive multifocal leukoencephalopathy is a rare, demyelinating disease of the central nervous system caused by JC virus. Fewer than 30 cases have been reported in HIV- and non-infected children. We report the case of a 15-year-old girl with progressive multifocal leukoencephalopathy and AIDS who presented with nystagmus, dysarthria and ataxia. Following combined antiretroviral therapy, she developed immune reconstitution inflammatory syndrome, which proved fatal.

Indexed as

AdolescentAdultBrainChildFatal OutcomeFemaleHumansImmune Reconstitution Inflammatory SyndromeJC VirusLeukoencephalopathy, Progressive MultifocalMagnetic Resonance ImagingMaleYoung Adult

Identifiers

PMID24632669
PMCPMC4020507
OpenAlexW2089368968

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.