Evidence map›Paper›PMID 24632608›Full record

Trial reportOncogene2015

MMP7-mediated cleavage of nucleolin at Asp255 induces MMP9 expression to promote tumor malignancy.

T-I Hsu, S-C Lin, P-S Lu, W-C Chang, C-Y Hung, Y-M Yeh, W-C Su, P-C Liao, J-J Hung

Erratum issuedAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Oncogene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

T-I Hsu1] Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng-Kung University, Tainan, Taiwan [2] Center for Infection Disease and Signal Transduction, National Cheng-Kung University, Tainan, Taiwan.
S-C LinInstitute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng-Kung University, Tainan, Taiwan.
P-S LuInstitute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng-Kung University, Tainan, Taiwan.
W-C Chang1] Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng-Kung University, Tainan, Taiwan [2] Center for Infection Disease and Signal Transduction, National Cheng-Kung University, Tainan, Taiwan [3] Institute of Basic Medical Sciences, National Cheng-Kung University, Tainan, Taiwan [4] Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan [5] Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
C-Y HungInstitute of Basic Medical Sciences, National Cheng-Kung University, Tainan, Taiwan.
Y-M YehDepartment of Internal Medicine, College of Medicine and Hospital, National Cheng-Kung University, Tainan, Taiwan.
W-C SuDepartment of Internal Medicine, College of Medicine and Hospital, National Cheng-Kung University, Tainan, Taiwan.
P-C LiaoDepartment of Environmental and Occupational Health, National Cheng-Kung University, Tainan, Taiwan.
J-J Hung1] Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng-Kung University, Tainan, Taiwan [2] Center for Infection Disease and Signal Transduction, National Cheng-Kung University, Tainan, Taiwan [3] Institute of Basic Medical Sciences, National Cheng-Kung University, Tainan, Taiwan [4] Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan [5] Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
National Cheng Kung University · TWNational Cheng Kung University Hospital · TWInstitute of Basic Medical Sciences of the Chinese Academy of Medical Sciences

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleolin (NCL) participates in DNA transcription, ribosomal biogenesis and the regulation of RNA stability. However, the contribution of NCL to tumor development is still not clear. Herein, we found that NCL expression correlated with poor prognosis in lung cancer patients. Overexpressed NCL was predominantly cleaved to C-terminal truncated NCL (TNCL). In lung cancer formation, activation of the epidermal growth factor receptor pathway induced NCL expression, and also the expression of matrix metalloproteinase (MMP) 7, which then cleaved NCL at Asp255 to generate TNCL of 55 kDa. TNCL increased the expression of several oncogenes, including MMP9, anaplastic lymphoma kinase (ALK), HIF1a and CBLB, and decreased the expression of tumor suppressors including BRD4, PCM1, TFG and KLF6 by modulating mRNA stability through binding to the 3'-untranslated regions of their transcripts, thus ultimately enhancing metastasis activity. In conclusion, this study identified a novel role of the cleavage form of NCL generated by MMP7 in stabilizing MMP9 mRNA. We also provide a new insight that MMP7 not only cleaves the extracellular matrix to promote tumor invasion but also cleaves NCL, which augment oncogenesis. Blocking NCL cleavage may provide a useful new strategy for lung cancer therapy.

Indexed as

Gene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticProteolysisAdaptor Proteins, Signal TransducingAgedAnaplastic Lymphoma KinaseAnimalsAutoantigensBromodomain Containing ProteinsCell Cycle ProteinsFemaleHumansHypoxia-Inducible Factor 1, alpha SubunitKruppel-Like Factor 6Kruppel-Like Transcription FactorsLung NeoplasmsAdaptor Proteins, Signal TransducingALK protein, humanAlk protein, mouseAnaplastic Lymphoma KinaseAutoantigensBRD4 protein, humanBromodomain Containing ProteinsCBLB protein, humanCell Cycle ProteinsHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitKLF6 protein, humanKruppel-Like Factor 6Kruppel-Like Transcription FactorsMatrix Metalloproteinase 7Matrix Metalloproteinase 9MMP7 protein, humanMMP9 protein, humanNuclear ProteinsNucleolinPCM1 protein, humanPhosphoproteinsProteinsProto-Oncogene ProteinsProto-Oncogene Proteins c-cblReceptor Protein-Tyrosine KinasesRNA-Binding ProteinsRNA, MessengerRNA, NeoplasmTFG protein, humanTranscription FactorsVesicular Transport Proteins

Identifiers

PMID24632608
OpenAlexW2022234739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.