Evidence map›Paper›PMID 24632509›Full record

ArticleAtherosclerosis2014

Comparing coronary artery calcium among U.S. South Asians with four racial/ethnic groups: the MASALA and MESA studies.

Alka M Kanaya, Namratha R Kandula, Susan K Ewing, David Herrington, Kiang Liu, Michael J Blaha, Shweta Srivastava, Swapna S Dave, Matthew J Budoff

Erratum issuedOpen access · greenAbstract readComparative Study
In one paragraph

Article in Atherosclerosis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.

  1. Guideline
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  13. Tailoring Calcium Scores to the Race of a Nation Not a Region.Journal of the American Heart Association · 2026
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Alka M KanayaUniversity of California, San Francisco, United States. Electronic address: alka.kanaya@ucsf.edu.
Namratha R KandulaNorthwestern University, United States.
Susan K EwingUniversity of California, San Francisco, United States.
David HerringtonWake Forest University Medical Center, United States.
Kiang LiuNorthwestern University, United States.
Michael J BlahaJohns Hopkins Ciccarone Center for the Prevention of Heart Disease, United States.
Shweta SrivastavaUniversity of California, San Francisco, United States.
Swapna S DaveNorthwestern University, United States.
Matthew J BudoffHarbor-University of California, Los Angeles, United States.
Northwestern University · USUniversity of California, San Francisco · USUniversity Medical Center · USUniversity of California, Los Angeles · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Mediators of Atherosclerosis in South Asians Living in AmericaR01HL093009 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2010 to 2018
$5.4M
Ectopic fat and atherosclerosis in South AsiansK24HL112827 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2013 to 2022
$1.2M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 1999 to 2006
$304k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READINGN01HC095169 · HC · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI DETRANO, ROBERT · 1999 to 2001
$124k
NCATS NIH HHS UL1 TR000004NCRR NIH HHS UL1 RR024131NHLBI NIH HHS K24 HL112827NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS R01 HL093009
6 · The paper itself

Abstract

objectivesSouth Asians (individuals from India, Pakistan, Bangladesh, Nepal, and Sri Lanka) have high rates of cardiovascular disease which cannot be explained by traditional risk factors. Few studies have examined coronary artery calcium (CAC) in South Asians.

methodsWe created a community-based cohort of South Asians in the United States and compared the prevalence and distribution of CAC to four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA). We compared 803 asymptomatic South Asians free of cardiovascular disease to the four MESA racial/ethnic groups (2622 Whites, 1893 African Americans, 1496 Latinos and 803 Chinese Americans).

resultsThe age-adjusted prevalence of any CAC was similar between White and South Asian men, but was lower in South Asian women compared to White women. After adjusting for all covariates associated with CAC, South Asian men were similar to White men and had higher CAC scores compared to African Americans, Latinos and Chinese Americans. In fully adjusted models, CAC scores were similar for South Asian women compared to all women enrolled in MESA. However, South Asian women ≥70 years had a higher prevalence of any CAC than most other racial/ethnic groups.

conclusionsSouth Asian men have similarly high CAC burden as White men, but higher CAC than other racial/ethnic groups. South Asian women appear to have similar CAC burden compared to other women, but have somewhat higher CAC burden in older age. The high burden of subclinical coronary atherosclerosis in South Asians may partly explain higher rates of cardiovascular disease in South Asians.

Indexed as

AsianBlack or African AmericanHispanic or LatinoWhite PeopleAdultAgedAged, 80 and overAtherosclerosisCalciumCoronary VesselsCross-Sectional StudiesFemaleHumansMaleMiddle AgedCalciumCoronary artery calciumEthnic differencesSouth AsiansSubclinical atherosclerosis

Identifiers

PMID24632509
PMCPMC4005416
OpenAlexW2008658164

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.