ArticleNeurobiology of disease2014
Diffusion fMRI detects white-matter dysfunction in mice with acute optic neuritis.
Article in Neurobiology of disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI.Nature communications · 2025Article
- Apparent Diffusion Coefficient fMRI shines light on white matter resting-state connectivity compared to BOLD.Communications biology · 2025Article
- Mapping Activity and Functional Organisation of the Motor and Visual Pathways Using ADC-fMRI in the Human Brain.Human brain mapping · 2025Article
- Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Whole-brain, gray, and white matter time-locked functional signal changes with simple tasks and model-free analysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Diffusion basis spectrum imaging detects subclinical traumatic optic neuropathy in a closed-head impact mouse model of traumatic brain injury.Frontiers in neurology · 2023Article
- Detection of functional activity in brain white matter using fiber architecture informed synchrony mapping.NeuroImage · 2022Article
- Microstructural changes of the vestibulocochlear nerve in patients with Ménière's disease using diffusion tensor imaging.Frontiers in neurology · 2022Article
- Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis.Frontiers in molecular neuroscience · 2022Review
- Mitochondrial-Respiration-Improving Effects of Three Different Gardeniae Fructus Preparations and Their Components.ACS omega · 2021Article
- Diffusion Basis Spectrum Imaging Detects Axonal Loss After Transient Dexamethasone Treatment in Optic Neuritis Mice.Frontiers in neuroscience · 2020Article
- Noninvasive Quantification of Axonal Loss in the Presence of Tissue Swelling in Traumatic Spinal Cord Injury Mice.Journal of neurotrauma · 2019Article
- MRI-based assessment of function and dysfunction in myelinated axons.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice.Journal of visualized experiments : JoVE · 2017Article
- Does functional MRI detect activation in white matter? A review of emerging evidence, issues, and future directions.Frontiers in neuroscience · 2014Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Optic neuritis is a frequent and early symptom of multiple sclerosis (MS). Conventional magnetic resonance (MR) techniques provide means to assess multiple MS-related pathologies, including axonal injury, demyelination, and inflammation. A method to directly and non-invasively probe white-matter function could further elucidate the interplay of underlying pathologies and functional impairments. Previously, we demonstrated a significant 27% activation-associated decrease in the apparent diffusion coefficient of water perpendicular to the axonal fibers (ADC⊥) in normal C57BL/6 mouse optic nerve with visual stimulation using diffusion fMRI. Here we apply this approach to explore the relationship between visual acuity, optic nerve pathology, and diffusion fMRI in the experimental autoimmune encephalomyelitis (EAE) mouse model of optic neuritis. Visual stimulation produced a significant 25% (vs. baseline) ADC⊥ decrease in sham EAE optic nerves, while only a 7% (vs. baseline) ADC⊥ decrease was seen in EAE mice with acute optic neuritis. The reduced activation-associated ADC⊥ response correlated with post-MRI immunohistochemistry determined pathologies (including inflammation, demyelination, and axonal injury). The negative correlation between activation-associated ADC⊥ response and visual acuity was also found when pooling EAE-affected and sham groups under our experimental criteria. Results suggest that reduction in diffusion fMRI directly reflects impaired axonal-activation in EAE mice with optic neuritis. Diffusion fMRI holds promise for directly gauging in vivo white-matter dysfunction or therapeutic responses in MS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.