ReviewCurrent opinion in neurobiology2014
The role of neuronal activity and transmitter release on synapse formation.
Review in Current opinion in neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed.
- Evidence supporting the role of GIGYF2 in synapse development and autism.Molecular psychiatry · 2026Article
- Iron Deficiency Impairs Mitochondrial Energetics and Early Axonal Growth and Branching in Developing Hippocampal Neurons.The Journal of nutrition · 2026Article
- Characterizing the Diversity of Layer 2/3 Human Neocortical Neurons in Pediatric Epilepsy.eNeuro · 2025Article
- Expression of synaptic proteins and development of dendritic spines in fetal and postnatal neocortex of the pig, the European wild boar Sus scrofa.Brain structure & function · 2025Article
- Neuronal activity-dependent gene expression is stimulus-specific and changes with neuronal maturation.Frontiers in molecular neuroscience · 2025Article
- Amygdala self-neuromodulation capacity as a window for process-related network recruitment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- SynBot is an open-source image analysis software for automated quantification of synapses.Cell reports methods · 2024Article
- An activity-regulated transcriptional program directly drives synaptogenesis.Nature neuroscience · 2024Article
- SynBot: An open-source image analysis software for automated quantification of synapses.bioRxiv : the preprint server for biology · 2024Article
- Association of Lack of Speech Arrest During Cortical Stimulation With Interhemispheric Reorganization of the Functional Language Network in Patients With Brain Tumors.AJR. American journal of roentgenology · 2023Article
- Effect of tumor genetics, pathology, and location on fMRI of language reorganization in brain tumor patients.European radiology · 2023Article
- Altered connectomes of adult-born granule cells following engraftment of GABAergic progenitors in the mouse hippocampus.Progress in neurobiology · 2023Article
- Endogenous Modulators of NMDA Receptor Control Dendritic Field Expansion of Cortical Neurons.Molecular neurobiology · 2023Article
- Role of glutamate in the development of visual pathways.Frontiers in ophthalmology · 2023Review
- Editorial: Emerging frontiers in developmental biology in Latin America.Frontiers in neuroscience · 2023Article
- Language reorganization in patients with left-hemispheric gliomas is associated with increased cortical volume in language-related areas and in the default mode network.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Adolescent sleep and the foundations of prefrontal cortical development and dysfunction.Progress in neurobiology · 2022Review
- Molecular mechanisms of synaptogenesis.Frontiers in synaptic neuroscience · 2022Review
- Understanding Language Reorganization With Neuroimaging: How Language Adapts to Different Focal Lesions and Insights Into Clinical Applications.Frontiers in human neuroscience · 2022Review
- Regulation of NMDA Receptor Signaling at Single Synapses by Human Anti-NMDA Receptor Antibodies.Frontiers in molecular neuroscience · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The long history of probing the role of neuronal activity in the development of nervous system circuitry has recently taken an interesting turn. Although undoubtedly activity plays a critical part in the maintenance and refinement of synaptic connections, often via competitive mechanisms, evidence is building that it also drives the process of synapse formation itself. Perhaps predictably, this turns out not to be a uniform process. It seems that different circuits, indeed specific synaptic connections, are differentially sensitive to the effects of activity. We examine possible ways in which neurotransmitter may drive synapse formation, and speculate on how the environment of the developing brain may allow a different spatiotemporal range for neuronal activity to operate in the generation of connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.