ArticleBiosensors & bioelectronics2014
Label-free detection of cardiac troponin I with a photonic crystal biosensor.
Article in Biosensors & bioelectronics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Real-time and label-free monitoring of monoclonal antibody secretion rates using a PC-TIR biosensor.Biosensors & bioelectronics · 2025Article
- Liver-on-a-Chip Integrated with Label-Free Optical Biosensors for Rapid and Continuous Monitoring of Drug-Induced Toxicity.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- A Highly Sensitive and Specific Photonic Crystal-Based Opioid Sensor with Rapid Regeneration.ACS applied materials & interfaces · 2023Article
- The role of antibody-based troponin detection in cardiovascular disease: A critical assessment.Journal of immunological methods · 2021Review
- Ultra Sensitivity Silicon-Based Photonic Crystal Microcavity Biosensors for Plasma Protein Detection in Patients with Pancreatic Cancer.Micromachines · 2020Article
- Enhancement of label-free biosensing of cardiac troponin I.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Prostate Cancer Epithelial Mesenchymal Transition by TGF-β1 exposure monitored with a Photonic Crystal Biosensor.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Cellular Refractive Index Comparison of Various Prostate Cancer and Noncancerous Cell Lines via Photonic-Crystal Biosensor.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Quality specification and status of internal quality control of cardiac biomarkers in China from 2011 to 2016.Journal of clinical laboratory analysis · 2018Article
- Article
- Limulus amoebocyte lysate test via an open-microcavity optical biosensor.Journal of biomedical optics · 2018Article
- Unique surface sensing property and enhanced sensitivity in microring resonator biosensors based on subwavelength grating waveguides.Optics express · 2016Article
- Handheld imaging photonic crystal biosensor for multiplexed, label-free protein detection.Biomedical optics express · 2015Article
- Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors.Applied physics letters · 2014Article
- Amino-functionalization of carbon nanotubes by using a factorial design: human cardiac troponin T immunosensing application.BioMed research international · 2014Article
- Label-freeProceedings of SPIE--the International Society for Optical EngineeringArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A biosensor has been developed with a photonic crystal structure used in a total-internal-reflection (PC-TIR) configuration for label-free detection of a cardiac biomarker: Troponin I (cTnI). In contrast to a conventional optical microcavity that has a closed structure with its cavity layer sandwiched between two high-reflection surfaces, the PC-TIR configuration creates a unique open microcavity, which allows its cavity layer (sensing layer) to be easily functionalized and directly exposed to analyte molecules for bioassays. In this study, a PC-TIR sensor has been used for the label-free measurements of cardiac biomarkers by monitoring the changes in the resonant condition of the cavity due to biomolecular binding processes. Antibodies against cTnI are immobilized on the sensor surface for specific detection of cTnI with a wide range of concentrations. Detection limit of cTnI with a concentration as low as 0.1ngmL(-1) has been achieved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.