Evidence map›Paper›PMID 24632109›Full record

Trial reportBehaviour research and therapy2014

Is weight gain really a catalyst for broader recovery?: The impact of weight gain on psychological symptoms in the treatment of adolescent anorexia nervosa.

Erin C Accurso, Anna C Ciao, Ellen E Fitzsimmons-Craft, James D Lock, Daniel Le Grange

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Behaviour research and therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. The Efficacy of Pharmacological Treatment of Depression in Anorexia Nervosa and Underweight Patients: A Systematic Review.European eating disorders review : the journal of the Eating Disorders Association · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Family therapy approaches for anorexia nervosa.The Cochrane database of systematic reviews · 2019
    Pooled it
  5. Family therapy approaches for anorexia nervosa.The Cochrane database of systematic reviews · 2018
    Pooled it
  6. Family-based treatment for adolescent anorexia nervosa: What happens to rates of comorbid diagnoses?European eating disorders review : the journal of the Eating Disorders Association · 2020
    Trial
  7. Trial
  8. Trial
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Weight Suppression and Risk for Childhood Psychiatric Disorders.Child psychiatry and human development · 2025
    Article
  15. Article
  16. Review
  17. Adolescent Patient Perspectives on Family-Based Treatment: A Pilot Study.The International journal of eating disorders · 2025
    Article
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Erin C AccursoDepartment of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 S. Maryland Ave., MC 3077, Chicago, IL 60637, USA. Electronic address: eaccurso@uchicago.edu.
Anna C CiaoDepartment of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 S. Maryland Ave., MC 3077, Chicago, IL 60637, USA.
Ellen E Fitzsimmons-CraftDepartment of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 S. Maryland Ave., MC 3077, Chicago, IL 60637, USA.
James D LockDepartment of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Rd., MC 5719, Stanford, CA 94305, USA.
Daniel Le GrangeDepartment of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 S. Maryland Ave., MC 3077, Chicago, IL 60637, USA.

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Regional Postdoctoral Training Grant in Eating Disorders ResearchT32MH082761 · NIMH · UNIVERSITY OF MINNESOTA · PI CAROL B. PETERSON · 2009 to 2026
$6.2M
Treatment of Adolescents with Anorexia NervosaR01MH070621 · NIMH · STANFORD UNIVERSITY · PI LOCK, JAMES D · 2004 to 2008
$2.0M
Mentoring and Research in Adolescent Eating DisordersK24MH074467 · NIMH · STANFORD UNIVERSITY · PI LOCK, JAMES D · 2005 to 2014
$1.9M
Treatment for Adolescent Anorexia NervosaR01MH070620 · NIMH · UNIVERSITY OF CHICAGO · PI LE GRANGE, DANIEL · 2004 to 2008
$1.4M
NCATS NIH HHS UL1 TR000430NIMH NIH HHS K24 MH074467NIMH NIH HHS R01 MH070620NIMH NIH HHS R01-MH-070620NIMH NIH HHS R01 MH070621NIMH NIH HHS R01-MH-070621NIMH NIH HHS T32 MH082761NIMH NIH HHS T32-MH-082761
6 · The paper itself

Abstract

The main aims of this study were to describe change in psychological outcomes for adolescents with anorexia nervosa across two treatments, and to explore predictors of change, including baseline demographic and clinical characteristics, as well as weight gain over time. Participants were 121 adolescents with anorexia nervosa from a two-site (Chicago and Stanford) randomized controlled trial who received either family-based treatment or individual adolescent supportive psychotherapy. Psychological symptoms (i.e., eating disorder psychopathology, depressive symptoms, and self-esteem) were assessed at baseline, end of treatment, 6-month, and 12-month follow-up. Conditional multilevel growth models were used to test for predictors of slope for each outcome. Most psychological symptoms improved significantly from baseline to 12 month follow-up, regardless of treatment type. Depressive symptoms and dietary restraint were most improved, weight and shape concerns were least improved, and self-esteem was not at all improved. Weight gain emerged as a significant predictor of improved eating disorder pathology, with earlier weight gain having a greater impact on symptom improvement than later weight gain. Adolescents who presented with more severe, complex, and enduring clinical presentations (i.e., longer duration of illness, greater eating disorder pathology, binge-eating/purging subtype) also appeared to benefit more psychologically from treatment.

Indexed as

Self ConceptWeight GainAdolescentAdolescent BehaviorAnorexia NervosaDepressionFamily TherapyFeeding BehaviorFemaleHumansMaleModels, BiologicalPsychotherapyAdolescent anorexia nervosaFamily-based treatmentOutcomePsychological recovery

Identifiers

PMID24632109
PMCPMC4019781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.