ReviewCurrent opinion in immunology2014
Regulatory constraints in the generation and differentiation of IgE-expressing B cells.
Review in Current opinion in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Mixed Signals: T Cells as Architects of IgE Immunity.Immunological reviews · 2026Review
- Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program.Immunity · 2025Article
- Evidence that High-Affinity IgE Can Develop in the Germinal Center in the Absence of an IgG1-Switched Intermediate.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Development of Adaptive Immunity and Its Role in Lung Remodeling.Advances in experimental medicine and biology · 2023Article
- Development of allergen-specific IgE in a food-allergy model requires precisely timed B cell stimulation and is inhibited by Fgl2.Cell reports · 2022Article
- Features of B Cell Responses Relevant to Allergic Disease.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- T Helper 2-Associated Immunity in the Pathogenesis of Systemic Lupus Erythematosus.Frontiers in immunology · 2022Review
- The Road Toward Transformative Treatments for Food Allergy.Frontiers in allergy · 2022Review
- Memory Generation and Re-Activation in Food Allergy.ImmunoTargets and therapy · 2021Review
- T follicular regulatory cells and IL-10 promote food antigen-specific IgE.The Journal of clinical investigation · 2020Article
- IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease.The Journal of allergy and clinical immunology · 2020Article
- IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells.The Journal of experimental medicine · 2020Article
- Regulation of IgE by T follicular helper cells.Journal of leukocyte biology · 2020Review
- Review
- The Multifaceted B Cell Response in Allergen Immunotherapy.Current allergy and asthma reports · 2018Review
- Gut Mucosal Antibody Responses and Implications for Food Allergy.Frontiers in immunology · 2018Review
- Study of IgE-Producing B Cells Using the Verigem Fluorescent Reporter Mouse.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Lifelong memory responses perpetuate humoral TThe Journal of allergy and clinical immunology · 2017Article
- IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE(+)) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE(+) B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE(+) B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE(+) B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.