Evidence map›Paper›PMID 24631943›Full record

ReviewAnnals of oncology : official journal of the European Society for Medical Oncology2014

Dairy products and pancreatic cancer risk: a pooled analysis of 14 cohort studies.

J M Genkinger, M Wang, R Li, D Albanes, K E Anderson, L Bernstein, P A van den Brandt, D R English, J L Freudenheim, C S Fuchs and 19 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of oncology : official journal of the European Society for Medical Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 7 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 7 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  3. Diets, Dietary Patterns, Single Foods and Pancreatic Cancer Risk: An Umbrella Review of Meta-Analyses.International journal of environmental research and public health · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 6 countries.

J M GenkingerDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York jg3081@columbia.edu.
M WangDepartment of Epidemiology, Harvard School of Public Health, Boston Department of Biostatistics, Harvard School of Public Health, Boston.
R LiDepartment of Epidemiology, Harvard School of Public Health, Boston.
D AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda.
K E AndersonDivision of Epidemiology and Community Health, School of Public Health, Masonic Cancer Center, University of Minnesota, Minneapolis.
L BernsteinDivision of Cancer Etiology, Department of Population Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, USA.
P A van den BrandtDepartment of Epidemiology, School for Oncology and Developmental Biology (GROW), Maastricht University, Maastricht, The Netherlands.
D R EnglishCancer Epidemiology Centre, Cancer Council of Victoria, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
J L FreudenheimDepartment of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo.
C S FuchsDivision of Medical Oncology, Dana-Farber Cancer Institute, Boston Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston.
S M GapsturEpidemiology Research Program, American Cancer Society, Atlanta, USA.
G G GilesCancer Epidemiology Centre, Cancer Council of Victoria, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
R A GoldbohmDepartment of Prevention and Health, TNO Quality of Life, Leiden, The Netherlands.
N HåkanssonDivision of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
P L Horn-RossCancer Prevention Institute of California, Fremont, USA.
A KoushikDepartment of Social and Preventive Medicine, University of Montreal, Montreal.
J R MarshallDepartment of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo.
M L McCulloughEpidemiology Research Program, American Cancer Society, Atlanta, USA.
A B MillerDalla Lana School of Public Health, University of Toronto, Toronto, Canada.
K RobienDepartment of Epidemiology and Biostatistics, School of Public Health and Health Services, George Washington University, Washington, DC.
T E RohanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, USA.
C SchairerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda.
D T SilvermanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda.
R Z Stolzenberg-SolomonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda.
J VirtamoDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
W C WillettDepartment of Epidemiology, Harvard School of Public Health, Boston Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston Department of Nutrition, Harvard School of Public Health, Boston, USA.
A WolkDivision of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
R G ZieglerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda.
S A Smith-WarnerDepartment of Epidemiology, Harvard School of Public Health, Boston Department of Nutrition, Harvard School of Public Health, Boston, USA.
Harvard University · USUnited States Department of Health and Human Services · USAmerican Cancer Society · USDivision of Cancer Epidemiology and GeneticsKarolinska Institutet · SEUniversity at Buffalo, State University of New York · USAlbert Einstein College of Medicine · USBrigham and Women's Hospital · USCancer Council Victoria · AUCancer Prevention Institute of California · USCity Of Hope National Medical Center · USColumbia University · USDana-Farber Cancer Institute · USFinnish Institute for Health and Welfare · FIGeorge Washington University · USMaastricht University · NLUniversité de Montréal · CAUniversity of Melbourne · AUUniversity of Minnesota · USUniversity of Toronto · CA

Funding

CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
EPIDEMIOLOGY OF CANCER IN A COHORT OF OLDER WOMENR01CA039742 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LAZOVICH, DEANN · 1985 to 2014
$8.0M
Research and Mentoring on Energetic Factors and Cancer: Established InvestigatorK05CA136967 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BERNSTEIN, LESLIE · 2009 to 2013
$684k
NCI NIH HHS CA139578NCI NIH HHS CA55075NCI NIH HHS K05 CA136967NCI NIH HHS R01 CA039742NCI NIH HHS R01 CA077398
6 · The paper itself

Abstract

Pancreatic cancer has few early symptoms, is usually diagnosed at late stages, and has a high case-fatality rate. Identifying modifiable risk factors is crucial to reducing pancreatic cancer morbidity and mortality. Prior studies have suggested that specific foods and nutrients, such as dairy products and constituents, may play a role in pancreatic carcinogenesis. In this pooled analysis of the primary data from 14 prospective cohort studies, 2212 incident pancreatic cancer cases were identified during follow-up among 862 680 individuals. Adjusting for smoking habits, personal history of diabetes, alcohol intake, body mass index (BMI), and energy intake, multivariable study-specific hazard ratios (MVHR) and 95% confidence intervals (CIs) were calculated using the Cox proportional hazards models and then pooled using a random effects model. There was no association between total milk intake and pancreatic cancer risk (MVHR = 0.98, 95% CI = 0.82-1.18 comparing ≥500 with 1-69.9 g/day). Similarly, intakes of low-fat milk, whole milk, cheese, cottage cheese, yogurt, and ice-cream were not associated with pancreatic cancer risk. No statistically significant association was observed between dietary (MVHR = 0.96, 95% CI = 0.77-1.19) and total calcium (MVHR = 0.89, 95% CI = 0.71-1.12) intake and pancreatic cancer risk overall when comparing intakes ≥1300 with <500 mg/day. In addition, null associations were observed for dietary and total vitamin D intake and pancreatic cancer risk. Findings were consistent within sex, smoking status, and BMI strata or when the case definition was limited to pancreatic adenocarcinoma. Overall, these findings do not support the hypothesis that consumption of dairy foods, calcium, or vitamin D during adulthood is associated with pancreatic cancer risk.

Indexed as

Cohort StudiesDairy ProductsDietHumansPancreatic NeoplasmsProportional Hazards ModelsRisk Factorscalcium intakedairy productspancreatic cancerpooled analysis

Identifiers

PMID24631943
PMCPMC4037857
OpenAlexW2161613264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.