Evidence map›Paper›PMID 24631581›Full record

ReviewDevelopmental and comparative immunology2014

The MHC class I genes of zebrafish.

Hayley Dirscherl, Sean C McConnell, Jeffrey A Yoder, Jill L O de Jong

Abstract readReview
In one paragraph

Review in Developmental and comparative immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  3. Review
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  8. Article
  9. Major Histocompatibility Complex in Osteichthyes.Journal of veterinary research · 2020
    Article
  10. Article
  11. Review
  12. Review
  13. Spotted Gar and the Evolution of Innate Immune Receptors.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2017
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hayley DirscherlDepartment of Molecular Biomedical Sciences, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA; The Joint Biomedical Engineering Graduate Program, University of North Carolina-North Carolina State University, Raleigh, NC, USA.
Sean C McConnellSection of Hematology-Oncology and Stem Cell Transplant, Department of Pediatrics, The University of Chicago, KCBD 5120, Chicago, IL 60637, USA.
Jeffrey A YoderDepartment of Molecular Biomedical Sciences, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA; Center for Comparative Medicine and Translational Research, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA. Electronic address: jayoder@ncsu.edu.
Jill L O de JongSection of Hematology-Oncology and Stem Cell Transplant, Department of Pediatrics, The University of Chicago, KCBD 5120, Chicago, IL 60637, USA. Electronic address: jdejong@peds.bsd.uchicago.edu.
North Carolina State University · USUniversity of Chicago · US

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Molecular Biotechnology Training at North Carolina State UniversityT32GM008776 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI KELLY, ROBERT M · 2000 to 2019
$3.9M
Mapping the functional major histocompatibility complex genes in zebrafishR03DK091497 · NIDDK · UNIVERSITY OF CHICAGO · PI DE JONG, JILL L · 2011 to 2012
$156k
NCATS NIH HHS UL1 TR000430NIDDK NIH HHS R03 DK091497NIGMS NIH HHS T32 GM008776NIGMS NIH HHS T32GM008776
6 · The paper itself

Abstract

Major histocompatibility complex (MHC) molecules play a central role in the immune response and in the recognition of non-self. Found in all jawed vertebrate species, including zebrafish and other teleosts, MHC genes are considered the most polymorphic of all genes. In this review we focus on the multi-faceted diversity of zebrafish MHC class I genes, which are classified into three sequence lineages: U, Z, and L. We examine the polygenic, polymorphic, and haplotypic diversity of the zebrafish MHC class I genes, discussing known and postulated functional differences between the different class I lineages. In addition, we provide the first comprehensive nomenclature for the L lineage genes in zebrafish, encompassing at least 15 genes, and characterize their sequence properties. Finally, we discuss how recent findings have shed new light on the remarkably diverse MHC loci of this species.

Indexed as

Genes, MHC Class IAnimalsHistocompatibility Antigens Class IMajor Histocompatibility ComplexPhylogenyZebrafishZebrafish ProteinsHistocompatibility Antigens Class IZebrafish ProteinsHaplotypeHistocompatibilityImmunityMHCMultigene familiesPolymorphism

Identifiers

PMID24631581
PMCPMC4031684
OpenAlexW2053668677

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.