ArticleThe EMBO journal1988
Villin expression in the visceral endoderm and in the gut anlage during early mouse embryogenesis.
Article in The EMBO journal, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 91 citations in OpenAlex.
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- Ezrin, a Membrane Cytoskeleton Cross-Linker Protein, as a Marker of Epithelial Damage in Asthma.American journal of respiratory and critical care medicine · 2019Article
- Blastocyst-Derived Stem Cell Populations under Stress: Impact of Nutrition and Metabolism on Stem Cell Potency Loss and Miscarriage.Stem cell reviews and reports · 2017Review
- Both BMP4 and serum have significant roles in differentiation of embryonic stem cells to primitive and definitive endoderm.Cytotechnology · 2016Article
- Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis.Mucosal immunology · 2014Article
- Mice overexpressing CD97 in intestinal epithelial cells provide a unique model for mammalian postnatal intestinal cylindrical growth.Molecular biology of the cell · 2013Article
- Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene.Developmental biology · 2011Article
- Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases.Molecular and cellular biology · 2004Article
- The gastrointestinal stem cell.Cell proliferation · 2004Review
- Reduction of renal mass is lethal in mice lacking vimentin. Role of endothelin-nitric oxide imbalance.The Journal of clinical investigation · 1997Article
- Normal tubular regeneration and differentiation of the post-ischemic kidney in mice lacking vimentin.The American journal of pathology · 1997Article
- Functional differences between L- and T-plastin isoforms.The Journal of cell biology · 1994Article
- Oval cell proliferation in early stages of hepatocarcinogenesis in simian virus 40 large T transgenic mice.The American journal of pathology · 1993Article
- Polarized distribution of neutral endopeptidase 24.11 at the cell surface of cultured human intestinal epithelial Caco-2 cells.The Biochemical journal · 1992Article
- Changes in keratin expression during fetal and postnatal development of intestinal epithelial cells.The Biochemical journal · 1992Article
- Structure of the human villin gene.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Immunohistochemical demonstration of villin in the normal human pancreas and in chronic pancreatitis.Histochemistry · 1991Article
- Microinjection of villin into cultured cells induces rapid and long-lasting changes in cell morphology but does not inhibit cytokinesis, cell motility, or membrane ruffling.The Journal of cell biology · 1990Article
- Expression of villin in the mouse oviduct and the seminiferous ducts.Histochemistry · 1990Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Villin is an evolutionarily well conserved, Ca2+ regulated actin-binding protein, and a major structural component of the brush border of specialized absorptive cells. Using paraffin sections and an affinity purified polyclonal anti-villin antibody, we have investigated the early expression of villin during mouse embryogenesis. Villin is first detectable at the early post-implantation stage in visceral endodermal cells at the periphery of the egg cylinder. In this extra embryonic layer, the expression of villin increases and then persists until full term gestation. In the embryo, villin first appears in gut anlage during the axial rotation. Using the same methodology, villin expression is also demonstrated in differentiating embryoid bodies from a teratocarcinoma. Both in extra embryonic and embryonic extracts, villin expression is confirmed by immunoblot and Northern blot analysis which reveal, respectively, a single polypeptide of 93 kd and an mRNA of 3.4 kb in length, two well defined parameters for adult mouse villin gene expression. The results presented here show that paraffin sections allow very sensitive and highly resolutive detection of antigens in early embryogenesis. They provide a detailed developmental profile of villin expression and demonstrate the usefulness of villin as a marker for epithelial cells involved in absorptive processes.
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