ArticleUltrasound in medicine & biology2014
In silico study of low-frequency transcranial ultrasound fields in acute ischemic stroke patients.
Article in Ultrasound in medicine & biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Transcranial ultrasound tomography for brain imaging: Ex vivo results and potential for stroke imaging.Medical physics · 2025Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Effect of Recombinant Tissue Plasminogen Activator and 120-kHz Ultrasound on Porcine Intracranial Thrombus Density.Ultrasound in medicine & biology · 2023Article
- Comparison between MR and CT imaging used to correct for skull-induced phase aberrations during transcranial focused ultrasound.Scientific reports · 2022Article
- Recent ultrasound advancements for the manipulation of nanobiomaterials and nanoformulations for drug delivery.Ultrasonics sonochemistry · 2021Review
- The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication.Journal of biomedical science · 2021Review
- Transcranial focused ultrasound phase correction using the hybrid angular spectrum method.Scientific reports · 2021Article
- Accelerated sonothrombolysis with Definity in a xenographic porcine cerebral thromboembolism model.Scientific reports · 2021Article
- Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers.Sensors (Basel, Switzerland) · 2020Review
- The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy in vitro.Physics in medicine and biology · 2019Article
- In vitro characterization of sonothrombolysis and echocontrast agents to treat ischemic stroke.Scientific reports · 2019Article
- A rapid beam simulation framework for transcranial focused ultrasound.Scientific reports · 2019Article
- Article
- Microfluidic manufacture of rt-PA -loaded echogenic liposomes.Biomedical microdevices · 2016Article
- Sonothrombolysis.Advances in experimental medicine and biology · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Ultrasound in the sub-megahertz range enhances thrombolysis and may be applied transcranially to ischemic stroke patients. The consistency of transcranial insonification needs to be evaluated. Acoustic and thermal simulations based on computed-tomography (CT) scans of 20 patients were performed. An unfocused 120-kHz transducer allowed homogeneous insonification of the thrombus, and positioning based on external landmarks performed similarly to an optimized placement based on CT data. With a weakly focused 500-kHz transducer, the landmark-based positioning underperformed. The predicted inter-patient variation of in situ acoustic pressure was similar with both the 120 and 500-kHz transducers for the optimized placement (18.0-26.4% relative standard deviation). The simulated maximum acoustic pressure in intervening tissues was 2.6 ± 0.6 and 2.0 ± 0.7 times the pressure in the thrombus for the 120-kHz and 500-kHz transducers, respectively. A 1 W/cm(2) insonification of the thrombus caused a 3.8 ± 2.2 °C increase in the bone for the 120-kHz transducer, and a 13.4 ± 3.3 °C increase for the 500-kHz transducer. Contralateral local maxima up to 1.1 times the pressure amplitude in the targeted zone were predicted for the 120-kHz transducer. We established two transducer placement approaches, one based on analysis of a head CT and the other using simple external, visible landmarks. Both approaches allowed consistent insonification of the thrombus.
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