Evidence map›Paper›PMID 24631356›Full record

ReviewSeminars in cell & developmental biology2014

From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease.

Bhuminder Singh, Robert J Coffey

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
  2. Review
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  9. Review
  10. Review
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  18. Establishment of Intestinal Organoid fromInternational journal of molecular sciences · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bhuminder SinghDepartments of Medicine and Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: bhuminder.singh@vanderbilt.edu.
Robert J CoffeyDepartments of Medicine and Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Veteran Affairs Medical Center, Nashville, TN 37232, USA. Electronic address: robert.coffey@vanderbilt.edu.

Funding

Understanding and Controlling p120 Dysfunction in CRCP50CA095103 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2002 to 2017
$33.6M
TRANSFORMING GROWTH FACTORS IN COLONIC NEOPLASIAR01CA046413 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 1988 to 2016
$8.8M
Roles for Lrig1 in Intestinal NeoplasiaR01CA151566 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2010 to 2016
$2.1M
Role of EGFR ligand-containing exosomes in colorectal cancerR01CA163563 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2013 to 2016
$1.7M
NCI NIH HHS P50 CA095103NCI NIH HHS R01 CA046413NCI NIH HHS R01 CA151566NCI NIH HHS R01 CA163563NCI NIH HHS R01 CA 46413
6 · The paper itself

Abstract

Since its discovery in 1978 and cloning in 1984, transforming growth factor-alpha (TGF-α, TGFA) has been one of the most extensively studied EGF receptor (EGFR) ligands. In this review, we provide a historical perspective on TGFA-related studies, highlighting what we consider important advances related to its function in normal and disease states.

Indexed as

AnimalsEGF Family of ProteinsEpidermal Growth FactorEpithelial CellsHairHumansSignal TransductionTransforming Growth Factor alphaEGF Family of ProteinsEpidermal Growth FactorTransforming Growth Factor alphaAutocrine singalingBasolateral traffickingEGFR, epidermal growth factor receptorMénétrier's diseasePolarized epithelial cellsTGFA, transforming growth factor alpha

Identifiers

PMID24631356
PMCPMC4105142

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.