ArticleGene2014
Integration of gene expression data with network-based analysis to identify signaling and metabolic pathways regulated during the development of osteoarthritis.
Article in Gene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Single-Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The potential molecular markers of inflammatory response in KOA with AD based on single-cell transcriptome sequencing analysis and identification of ligands by virtual screening.Molecular diversity · 2025Article
- Chemokines in Cartilage Regeneration and Degradation: New Insights.International journal of molecular sciences · 2023Review
- Role of the hedgehog signaling pathway in rheumatic diseases: An overview.Frontiers in immunology · 2022Review
- Accelerating functional gene discovery in osteoarthritis.Nature communications · 2021Article
- Evaluation of CCL21 role in post-knee injury inflammation and early cartilage degeneration.PloS one · 2021Article
- Anti-Inflammatory Effects of BoNT/A Against Complete Freund's Adjuvant-Induced Arthritis Pain in Rats: Transcriptome Analysis.Frontiers in pharmacology · 2021Article
- Brief introduction of medical database and data mining technology in big data era.Journal of evidence-based medicine · 2020Review
- Multi-tissue network analysis for drug prioritization in knee osteoarthritis.Scientific reports · 2019Article
- Network module identification-A widespread theoretical bias and best practices.Methods (San Diego, Calif.) · 2018Article
- Wnt5a induces catabolic signaling and matrix metalloproteinase production in human articular chondrocytes.Osteoarthritis and cartilage · 2017Article
- Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Association between Single Nucleotide Polymorphisms ofJournal of clinical and diagnostic research : JCDR · 2017Article
- Chemokines and inflammation in osteoarthritis: Insights from patients and animal models.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Review
- Screening of gene signatures for rheumatoid arthritis and osteoarthritis based on bioinformatics analysis.Molecular medicine reports · 2016Article
- The microRNA-29 family in cartilage homeostasis and osteoarthritis.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Animal models of osteoarthritis: classification, update, and measurement of outcomes.Journal of orthopaedic surgery and research · 2016Review
- Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation.RMD open · 2016Review
- Inflammation in joint injury and post-traumatic osteoarthritis.Osteoarthritis and cartilage · 2015Review
- Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Osteoarthritis (OA) is characterized by remodeling and degradation of joint tissues. Microarray studies have led to a better understanding of the molecular changes that occur in tissues affected by conditions such as OA; however, such analyses are limited to the identification of a list of genes with altered transcript expression, usually at a single time point during disease progression. While these lists have identified many novel genes that are altered during the disease process, they are unable to identify perturbed relationships between genes and gene products. In this work, we have integrated a time course gene expression dataset with network analysis to gain a better systems level understanding of the early events that occur during the development of OA in a mouse model. The subnetworks that were enriched at one or more of the time points examined (2, 4, 8, and 16 weeks after induction of OA) contained genes from several pathways proposed to be important to the OA process, including the extracellular matrix-receptor interaction and the focal adhesion pathways and the Wnt, Hedgehog and TGF-β signaling pathways. The genes within the subnetworks were most active at the 2 and 4 week time points and included genes not previously studied in the OA process. A unique pathway, riboflavin metabolism, was active at the 4 week time point. These results suggest that the incorporation of network-type analyses along with time series microarray data will lead to advancements in our understanding of complex diseases such as OA at a systems level, and may provide novel insights into the pathways and processes involved in disease pathogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.