Evidence map›Paper›PMID 24630812›Full record

ReviewCell metabolism2014

Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications.

Yvonne M Ulrich-Lai, Karen K Ryan

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 105 citations in OpenAlex.

  1. The Acute Relationship between Affective States and Stress Biomarkers in Ethnic Minority Youths.International journal of environmental research and public health · 2021
    Trial
  2. Review
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  7. Mechanisms of Lipid-Associated Macrophage Accrual in Metabolically Stressed Adipose Tissue.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yvonne M Ulrich-LaiDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA.
Karen K RyanDepartment of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA. Electronic address: karen.ryan@uc.edu.
University of Cincinnati Medical Center · US

Funding

Food Reward and StressR01DK091425 · NIDDK · UNIVERSITY OF CINCINNATI · PI ULRICH-LAI, YVONNE MICHELLE · 2011 to 2015
$1.7M
CNS PPARg, stress, and cardiovascular diseaseR00HL111319 · NHLBI · UNIVERSITY OF CINCINNATI · PI RYAN, KAREN · 2014 to 2016
$749k
CNS PPARg, Stress, & Cardiovascular DiseaseK99HL111319 · NHLBI · UNIVERSITY OF CINCINNATI · PI RYAN, KAREN · 2012 to 2013
$238k
NHLBI NIH HHS HL111319NHLBI NIH HHS K99 HL111319NHLBI NIH HHS R00 HL111319NIDDK NIH HHS DK091425NIDDK NIH HHS R01 DK091425
6 · The paper itself

Abstract

Significant comorbidities between obesity-related metabolic disease and stress-related psychological disorders suggest important functional interactions between energy balance and brain stress integration. Largely overlapping neural circuits control these systems, and this anatomical arrangement optimizes opportunities for mutual influence. Here we first review the current literature identifying effects of metabolic neuroendocrine signals on stress regulation, and vice versa. Next, the contributions of reward-driven food intake to these metabolic and stress interactions are discussed. Lastly, we consider the interrelationships between metabolism, stress, and reward in light of their important implications in the development of therapies for metabolism- or stress-related disease.

Indexed as

AdiposityBrainEatingEnergy MetabolismHumansMetabolic SyndromeNeurosecretory SystemsObesityRewardSignal TransductionStress, Psychological

Identifiers

PMID24630812
PMCPMC4047143
OpenAlexW2092627782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.