Evidence map›Paper›PMID 24630521›Full record

ArticleThe Journal of surgical research2014

Short-term physical inactivity impairs vascular function.

Emily V Nosova, Priscilla Yen, Karen C Chong, Hugh F Alley, Eveline O Stock, Alex Quinn, Jason Hellmann, Michael S Conte, Christopher D Owens, Matthew Spite and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Peripheral vascular function in stroke: systematic review and meta-analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Metabolic Implications of Diet and Energy Intake during Physical Inactivity.Medicine and science in sports and exercise · 2019
    Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Article
  15. Article
  16. Article
  17. Article
  18. Activity after an acute cardiovascular event-room for improvement!Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Emily V NosovaDepartment of Surgery, University of California, San Francisco, California; VIPERx Laboratory, San Francisco, California.
Priscilla YenDepartment of Biostatistics, University of California, Los Angeles, California.
Karen C ChongDepartment of Surgery, University of California, San Francisco, California; VIPERx Laboratory, San Francisco, California.
Hugh F AlleyDepartment of Surgery, University of California, San Francisco, California; VIPERx Laboratory, San Francisco, California.
Eveline O StockCardiovascular Research Institute, University of California, San Francisco, California; Department of Medicine, University of California, San Francisco, California.
Alex QuinnCardiovascular Research Institute, University of California, San Francisco, California.
Jason HellmannDivision of Cardiovascular Medicine, University of Louisville, Kentucky.
Michael S ConteDepartment of Surgery, University of California, San Francisco, California; Cardiovascular Research Institute, University of California, San Francisco, California.
Christopher D OwensDepartment of Surgery, University of California, San Francisco, California; VIPERx Laboratory, San Francisco, California; Department of Surgery, Veterans Affairs Medical Center, San Francisco, California.
Matthew SpiteDivision of Cardiovascular Medicine, University of Louisville, Kentucky.
S Marlene GrenonDepartment of Surgery, University of California, San Francisco, California; VIPERx Laboratory, San Francisco, California; Department of Surgery, Veterans Affairs Medical Center, San Francisco, California. Electronic address: marlene.grenon@ucsfmedctr.org.
University of California, San Francisco · USSan Francisco VA Medical Center · USUniversity of Louisville · USUniversity of California, Los Angeles · US

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
Project 5 - Metabolomic Analysis of AtherothrombosisP20GM103492 · NIGMS · UNIVERSITY OF LOUISVILLE · PI BHATNAGAR, ARUNI · 2012 to 2017
$13.8M
Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
NCATS NIH HHS KL2 TR000143NCRR NIH HHS KL2 RR024130NIGMS NIH HHS P20 GM103492
6 · The paper itself

Abstract

backgroundSedentarism, also termed physical inactivity, is an independent risk factor for cardiovascular diseases. Mechanisms thought to be involved include insulin resistance, dyslipidemia, hypertension, and increased inflammation. It is unknown whether changes in vascular and endothelial function also contribute to this excess risk. We hypothesized that short-term exposure to inactivity would lead to endothelial dysfunction, arterial stiffening, and increased vascular inflammation.

methodsFive healthy subjects (four men and one woman) underwent 5 d of bed rest (BR) to simulate inactivity. Measurements of vascular function (flow-mediated vasodilation to evaluate endothelial function; applanation tonometry to assess arterial resistance), inflammation, and metabolism were made before BR, daily during BR, and 2 d after BR recovery period. Subjects maintained an isocaloric diet throughout.

resultsBR led to significant decreases in brachial artery and femoral artery flow-mediated vasodilation (brachial: 11 ± 3% pre-BR versus 9 ± 2% end-BR, P = 0.04; femoral: 4 ± 1% versus 2 ± 1%, P = 0.04). The central augmentation index increased with BR (-4 ± 9% versus 5 ± 11%, P = 0.03). Diastolic blood pressure increased (58 ± 7 mm Hg versus 62 ± 7 mm Hg, P = 0.02), whereas neither systolic blood pressure nor heart rate changed. 15-Hydroxyeicosatetraenoic acid, an arachidonic acid metabolite, increased but the other inflammatory and metabolic biomarkers were unchanged.

conclusionsOur findings show that acute exposure to sedentarism results in decreased endothelial function, arterial stiffening, increased diastolic blood pressure, and an increase in 15-hydroxyeicosatetraenoic acid. We speculate that inactivity promotes a vascular "deconditioning" state characterized by impaired endothelial function, leading to arterial stiffness and increased arterial tone. Although physiologically significant, the underlying mechanisms and clinical relevance of these findings need to be further explored.

Indexed as

Sedentary BehaviorVascular StiffnessBed RestBiomarkersBlood PressureEndothelium, VascularFemaleHealthy VolunteersHumansHydroxyeicosatetraenoic AcidsInflammationMaleYoung AdultBiomarkersHydroxyeicosatetraenoic AcidsArterial stiffnessEndothelial dysfunctionInflammationPhysical inactivity

Identifiers

PMID24630521
PMCPMC4096607
OpenAlexW2051228488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.