ArticleJournal of psychiatric research2014
Do prefrontal midline electrodes provide unique neurophysiologic information in Major Depressive Disorder?
Article in Journal of psychiatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Resting-state EEG activity in depression: a systematic review and meta-analysis.NeuroImage. Clinical · 2026Pooled it
- The relationship between emotional regulation and hemispheric lateralization in depression: a systematic review and a meta-analysis.Translational psychiatry · 2022Pooled it
- Sexual dimorphism in cortical theta rhythms relates to elevated internalizing symptoms during adolescence.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Magnetic seizure therapy and electroconvulsive therapy increase aperiodic activity.Translational psychiatry · 2023Article
- Magnetic seizure therapy and electroconvulsive therapy increase aperiodic activity.medRxiv : the preprint server for health sciences · 2023Article
- Resting State EEG Correlates of Suicide Ideation and Suicide Attempt.Journal of personalized medicine · 2023Review
- In-silico EEG biomarkers of reduced inhibition in human cortical microcircuits in depression.PLoS computational biology · 2023Article
- Prospective testing of a neurophysiologic biomarker for treatment decisions in major depressive disorder: The PRISE-MD trial.Journal of psychiatric research · 2020Article
- EEG Frequency Bands in Psychiatric Disorders: A Review of Resting State Studies.Frontiers in human neuroscience · 2018Review
- Resting-state EEG delta power is associated with psychological pain in adults with a history of depression.Biological psychology · 2015Article
- Intermediate phenotypes and biomarkers of treatment outcome in major depressive disorder.Dialogues in clinical neuroscience · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Brain oscillatory activity from the midline prefrontal region has been shown to reflect brain dysfunction in subjects with Major Depressive Disorder (MDD). It is not known, however, whether electrodes from this area provide unique information about brain function in MDD. We examined a set of midline sites and two other prefrontal locations for detecting cerebral activity differences between subjects with MDD and healthy controls. Resting awake quantitative EEG (qEEG) data were recorded from 168 subjects: 47 never-depressed adults and 121 with a current major depressive episode. Individual midline electrodes (Fpz, Fz, Cz, Pz, and Oz) and prefrontal electrodes outside the hairline (Fp1, Fp2) were examined with absolute and relative power and cordance in the theta band. We found that MDD subjects exhibited higher values of cordance (p = 0.0066) at Fpz than controls; no significant differences were found at other locations, and power measures showed trend-level differences. Depressed adults showed higher midline cordance than did never-depressed subjects at the most-anterior midline channel. Salient abnormalities in MDD may be detectable by focusing on the prefrontal midline region, and EEG metrics from focused electrode arrays may offer clinical practicality for clinical monitoring.
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