Evidence map›Paper›PMID 24629894›Full record

ArticleJournal of neuroimmunology2014

Morphine increases hippocampal viral load and suppresses frontal lobe CCL5 expression in the LP-BM5 AIDS model.

Virginia D McLane, Ling Cao, Colin L Willis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Effects of Morphine on Gp120-induced Neuroinflammation Under Immunocompetent Vs. Immunodeficient Conditions.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023
    Article
  4. Effects of HIV gp120 on Neuroinflammation in Immunodeficient vs. Immunocompetent States.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Article
  5. Effect of Opioid Use on Immune Activation and HIV Persistence on ART.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  6. Opioid and neuroHIV Comorbidity - Current and Future Perspectives.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Virginia D McLaneGraduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME 04473, USA; Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA; Center for Excellence in the Neurosciences, University of New England, Biddeford, ME 04005, USA. Electronic address: vdmclane@gmail.com.
Ling CaoDepartment of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA; Center for Excellence in the Neurosciences, University of New England, Biddeford, ME 04005, USA.
Colin L WillisDepartment of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA; Center for Excellence in the Neurosciences, University of New England, Biddeford, ME 04005, USA.
University of Maine · USUniversity of New England · US

Funding

Tissue resident macrophages in sensory ganglia: function and impact on nociceptionP20GM103643 · NIGMS · UNIVERSITY OF NEW ENGLAND · PI MENG, IAN D · 2012 to 2021
$20.9M
Murine AIDS (LP-BM5) viral infection induced peripheral neuropathy - Role of CNSR21NS066130 · NINDS · UNIVERSITY OF NEW ENGLAND · PI CAO, LING · 2009 to 2010
$331k
NIGMS NIH HHS P20 GM103643NIGMS NIH HHS P20GM103643NINDS NIH HHS 5R21NS066130NINDS NIH HHS R21 NS066130
6 · The paper itself

Abstract

Chronic opiate abuse accelerates the development of cognitive deficits in human immunodeficiency virus (HIV)-1 patients. To investigate morphine's effects on viral infection of the central nervous system, we applied chronic morphine treatment to the LP-BM5 murine acquired immunodeficiency syndrome (MAIDS) model. LP-BM5 infection induces proinflammatory cytokine/chemokine production, correlating to increased blood-brain barrier permeability. Morphine treatment significantly increased LP-BM5 viral load in the hippocampus, but not in the frontal lobe. Morphine reduced the chemokine CCL5 to non-infected levels in the frontal lobe, but not in the hippocampus. These data indicate a region-specific mechanism for morphine's effects on virally-induced neurocognitive deficits.

Indexed as

Acquired Immunodeficiency SyndromeAnimalsChemokine CCL5Frontal LobeGene Expression RegulationHippocampusMaleMiceMice, Inbred C57BLMorphineMurine Acquired Immunodeficiency SyndromeViral LoadCcl5 protein, mouseChemokine CCL5MorphineBlood–brain barrierClaudin-5CytokinesHIV encephalitisNeuroinflammationOpiate abuse

Identifiers

PMID24629894
PMCPMC4026271
OpenAlexW1978377197

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.