Evidence map›Paper›PMID 24629537›Full record

ArticleBiological psychiatry2014

Default mode network mechanisms of transcranial magnetic stimulation in depression.

Conor Liston, Ashley C Chen, Benjamin D Zebley, Andrew T Drysdale, Rebecca Gordon, Bruce Leuchter, Henning U Voss, B J Casey, Amit Etkin, Marc J Dubin

6 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 380 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
380citing papers in PubMed, 6 pooled it
19.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03687892 naterminatednot on this mapstarted 2019, after this paper: background citation

Establishing Functional Biomarkers for Spaced Theta-Burst Stimulation

TypeinterventionalSponsorStanford UniversityRan2019 to 2022Enrolled37ConditionsHealthy VolunteersArmscontinuous Theta Burst Stimulation, intermittent Theta Burst Stimulation
NCT03693105 phase2 / phase3terminatednot on this mapstarted 2024, after this paper: background citation

A Multi-Site, Randomized, Double-Blind Trial Assessing The Effects of SAINT® Neuromodulation System on Explicit and Implicit Suicidal Cognition

TypeinterventionalSponsorMagnus MedicalRan2024 to 2025Enrolled2ConditionsMajor Depressive Disorder, Major Depressive Episode, Suicidal IdeationArmsActive SAINT Stimulation, Sham SAINT Stimulation
NCT03944213 unknown statusnot on this mapstarted 2018, after this paper: background citation

Resting-state Functional Connectivity Throughout a Course of iTBS in Major Depression

TypeobservationalSponsorUniversity Hospital, BonnRan2018 to 2024Enrolled60ConditionsDepression, Depressive Disorder, Depressive Disorder, Major, Depressive EpisodeArmsintermittent theta burst stimulation (iTBS)
NCT04870255 narecruitingnot on this mapstarted 2021, after this paper: background citation

Modulating Probabilities: Prediction, Assessment, and Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS

TypeinterventionalSponsorStanford UniversityRan2021 to 2026Enrolled45ConditionsDepressive Disorder, Major, Borderline Personality DisorderArmsLeft Dorsolateral Prefrontal Cortex (L-DLPFC), Dorsomedial Prefrontal Cortex (DMPFC), Sham Stimulation
NCT05100004 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Rapid Acting Transcranial Magnetic Stimulation for Suicide Ideation in Depression

TypeinterventionalSponsorStanford UniversityRan2021 to 2025Enrolled0ConditionsDepressive Disorder, Major, SuicideArmsAccelerated Theta Burst Stimulation, Sham Stimulation
NCT07684911 recruitingnot on this mapstarted 2026, after this paper: background citation

Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols - Biomarkers

TypeobservationalSponsorHospital Center Guillaume RégnierRan2026 to 2029Enrolled30ConditionsDepression - Major Depressive Disorder, Depression Bipolar, Depression UnipolarArmsRepetitive transcranial magnetic stimulation
3 · Its place in the literature

Who cites it

380 citing papers in PubMed, 6 syntheses or guidelines pooled it, 741 citations in OpenAlex.

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320 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Conor ListonDepartment of Psychiatry and Behavioral Sciences (CL, ACC, AE), Stanford University School of Medicine, Palo Alto, California; Brain and Mind Research Institute and Department of Psychiatry (CL, ATD, RG, BL, BJC, MJD), Weill Cornell Medical College. Electronic address: col2004@med.cornell.edu.
Ashley C ChenDepartment of Psychiatry and Behavioral Sciences (CL, ACC, AE), Stanford University School of Medicine, Palo Alto, California; Sierra-Pacific Mental Illness Research, Education, and Clinical Center (ACC, AE), Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
Benjamin D ZebleyDepartment of Psychiatry (BDZ), Columbia University College of Physicians and Surgeons.
Andrew T DrysdaleBrain and Mind Research Institute and Department of Psychiatry (CL, ATD, RG, BL, BJC, MJD), Weill Cornell Medical College.
Rebecca GordonBrain and Mind Research Institute and Department of Psychiatry (CL, ATD, RG, BL, BJC, MJD), Weill Cornell Medical College.
Bruce LeuchterBrain and Mind Research Institute and Department of Psychiatry (CL, ATD, RG, BL, BJC, MJD), Weill Cornell Medical College.
Henning U VossDepartment of Radiology (HUV), Weill Cornell Medical College, New York, New York.
B J CaseyBrain and Mind Research Institute and Department of Psychiatry (CL, ATD, RG, BL, BJC, MJD), Weill Cornell Medical College.
Amit EtkinDepartment of Psychiatry and Behavioral Sciences (CL, ACC, AE), Stanford University School of Medicine, Palo Alto, California; Sierra-Pacific Mental Illness Research, Education, and Clinical Center (ACC, AE), Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
Marc J DubinBrain and Mind Research Institute and Department of Psychiatry (CL, ATD, RG, BL, BJC, MJD), Weill Cornell Medical College.
Cornell University · USMIND Research Institute · USStanford University · USColumbia College · CAVA Palo Alto Health Care System · US

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Statistical Genetics Core: Impact of BDNF Genotype and Stress on LearningP50MH079513 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI CASEY, BETTY J · 2008 to 2012
$9.4M
Chronic Stress Effects on Connectivity in a Limbic CircuitR00MH097822 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LISTON, CONOR M · 2014 to 2016
$747k
Chronic Stress Effects on Connectivity in a Limbic CircuitK99MH097822 · NIMH · STANFORD UNIVERSITY · PI LISTON, CONOR M · 2012 to 2013
$209k
NIGMS NIH HHS T32 GM007739NIMH NIH HHS K99 MH097822NIMH NIH HHS P50 MH079513NIMH NIH HHS P50-MH079513NIMH NIH HHS R00 MH097822
6 · The paper itself

Abstract

backgroundRepetitive transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal cortex (DLPFC) is an established treatment for depression, but its underlying mechanism of action remains unknown. Abnormalities in two large-scale neuronal networks-the frontoparietal central executive network (CEN) and the medial prefrontal-medial parietal default mode network (DMN)-are consistent findings in depression and potential therapeutic targets for TMS. Here, we assessed the impact of TMS on activity in these networks and their relation to treatment response.

methodsWe used resting state functional magnetic resonance imaging to measure functional connectivity within and between the DMN and CEN in 17 depressed patients, before and after a 5-week course of TMS. Motivated by prior reports, we focused on connectivity seeded from the DLPFC and the subgenual cingulate, a key region closely aligned with the DMN in depression. Connectivity was also compared with a cohort of 35 healthy control subjects.

resultsBefore treatment, functional connectivity in depressed patients was abnormally elevated within the DMN and diminished within the CEN, and connectivity between these two networks was altered. Transcranial magnetic stimulation normalized depression-related subgenual hyperconnectivity in the DMN but did not alter connectivity in the CEN. Transcranial magnetic stimulation also induced anticorrelated connectivity between the DLPFC and medial prefrontal DMN nodes. Baseline subgenual connectivity predicted subsequent clinical improvement.

conclusionsTranscranial magnetic stimulation selectively modulates functional connectivity both within and between the CEN and DMN, and modulation of subgenual cingulate connectivity may play an important mechanistic role in alleviating depression. The results also highlight potential neuroimaging biomarkers for predicting treatment response.

Indexed as

Transcranial Magnetic StimulationAdultBrainBrain MappingFemaleHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleMiddle AgedNerve NetCentral executive networkdefault mode networkdepressionresting state fMRITMS

Identifiers

PMID24629537
PMCPMC4209727
OpenAlexW1987464027

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.