ReviewDNA repair2014
Studying the organization of DNA repair by single-cell and single-molecule imaging.
Review in DNA repair, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Assessing the variation of DNA damage response of individual human cells exposed to photon radiation.Radiation and environmental biophysics · 2026Article
- Deciphering the Ubiquitin-like Code of DNA-PK: Mechanisms and Therapeutic Opportunities.Biomolecules · 2026Review
- The role of environmental stress in promoting mutators through evolutionary rescue: quantitative predictions.Genetics · 2025Article
- Single-molecule imaging of SWI/SNF chromatin remodelers reveals bromodomain-mediated and cancer-mutants-specific landscape of multi-modal DNA-binding dynamics.Nature communications · 2024Article
- Visualization, Quantification, and Statistical Evaluation of Dynamics for DNA-Binding Proteins in Bacteria by Single-Molecule Tracking.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Bacterial Vivisection: How Fluorescence-Based Imaging Techniques Shed a Light on the Inner Workings of Bacteria.Microbiology and molecular biology reviews : MMBR · 2020Review
- Bacterial phenotypic heterogeneity in DNA repair and mutagenesis.Biochemical Society transactions · 2020Review
- Comparison of Escherichia coli surface attachment methods for single-cell microscopy.Scientific reports · 2019Article
- A Quantitative Model Explains Single-Cell Dynamics of the Adaptive Response in Escherichia coli.Biophysical journal · 2019Article
- From single bacterial cell imaging towardsEssays in biochemistry · 2019Review
- Understanding Protein Mobility in Bacteria by Tracking Single Molecules.Journal of molecular biology · 2018Review
- Simultaneous dual-channel imaging to quantify interdependent protein recruitment to laser-induced DNA damage sites.Nucleus (Austin, Tex.) · 2018Article
- Beyond the bulk: disclosing the life of single microbial cells.FEMS microbiology reviews · 2017Review
- Review
- Deconvolution of Gene Expression Noise into Spatial Dynamics of Transcription Factor-Promoter Interplay.ACS synthetic biology · 2017Article
- A Critical and Comparative Review of Fluorescent Tools for Live-Cell Imaging.Annual review of physiology · 2017Review
- How are base excision DNA repair pathways deployedF1000Research · 2017Review
- DNA Sequence Alignment during Homologous Recombination.The Journal of biological chemistry · 2016Review
- Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation.Science (New York, N.Y.) · 2016Article
- Regulation of recombination and genomic maintenance.Cold Spring Harbor perspectives in biology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
DNA repair safeguards the genome against a diversity of DNA damaging agents. Although the mechanisms of many repair proteins have been examined separately in vitro, far less is known about the coordinated function of the whole repair machinery in vivo. Furthermore, single-cell studies indicate that DNA damage responses generate substantial variation in repair activities across cells. This review focuses on fluorescence imaging methods that offer a quantitative description of DNA repair in single cells by measuring protein concentrations, diffusion characteristics, localizations, interactions, and enzymatic rates. Emerging single-molecule and super-resolution microscopy methods now permit direct visualization of individual proteins and DNA repair events in vivo. We expect much can be learned about the organization of DNA repair by linking cell heterogeneity to mechanistic observations at the molecular level.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.