Evidence map›Paper›PMID 24629344›Full record

ArticleCell host & microbe2014

The treatment-naive microbiome in new-onset Crohn's disease.

Dirk Gevers, Subra Kugathasan, Lee A Denson, Yoshiki Vázquez-Baeza, Will Van Treuren, Boyu Ren, Emma Schwager, Dan Knights, Se Jin Song, Moran Yassour and 22 more

4 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 1,855 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,855citing papers in PubMed, 7 pooled it
168.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02709694 completednot on this mapstarted 2016, after this paper: background citation

Imaging Biomarkers in Crohn's Associated Spondyloarthritis

TypeobservationalSponsorHospital for Special Surgery, New YorkRan2016 to 2021Enrolled33ConditionsCrohn's Disease, SpondyloarthritisArmsNo intervention
NCT03291743 naterminatednot on this mapstarted 2017, after this paper: background citation

The Biologic Onset of Crohn's Disease: A Screening Study in First Degree Relatives

TypeinterventionalSponsorCarilion ClinicRan2017 to 2022Enrolled38ConditionsCrohn Disease, Genetic Predisposition, IBDArmsCapsule endoscopy
NCT03378167 phase1completednot on this mapstarted 2018, after this paper: background citation

PediCRaFT: Pediatric Crohn's Disease Fecal Microbiota Transplant Pilot Study

TypeinterventionalSponsorMcMaster Children's HospitalRan2018 to 2023Enrolled17ConditionsCrohn Disease, Pediatric Crohns Disease, Inflammatory Bowel Diseases, ColitisArmsMICROBIOTA, PLACEBO
NCT04376203 unknown statusnot on this mapstarted 2020, after this paper: background citation

What is the Relation of Microbiome to Papillary Thyroid Microcarcinoma Development?

TypeobservationalSponsorUniversity of IoanninaRan2020 to 2023Enrolled40ConditionsPapillary Thyroid Microcarcinoma, MicrobiomeArmsThyroidectomy
3 · Its place in the literature

Who cites it

1,855 citing papers in PubMed, 7 syntheses or guidelines pooled it, 3,244 citations in OpenAlex.

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  15. The role of adhesins ofGut microbes · 2026
    Review
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1,795 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors at 18 institutions in 2 countries.

Dirk GeversBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Subra Kugathasan *Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University, Atlanta, GA 30322, USA.
Lee A Denson *Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Yoshiki Vázquez-BaezaDepartment of Computer Science, University of Colorado, Boulder, Colorado 80309, USA.
Will Van TreurenBioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA.
Boyu RenDepartment of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
Emma SchwagerDepartment of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
Dan KnightsDepartment of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55108, USA.
Se Jin SongBioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA.
Moran YassourBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Xochitl C MorganDepartment of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
Aleksandar D KosticBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Chengwei LuoBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Antonio GonzálezBioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA.
Daniel McDonaldBioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA.
Yael HabermanDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Thomas WaltersDivision of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
Susan BakerChildren's Hospital of Buffalo, Buffalo, NY 14222, USA.
Joel RoshGoryeb Children's Hospital, Morristown, NJ 07960, USA.
Michael StephensMayo Clinic, Rochester, MN 55902, USA.
Melvin HeymanUniversity of California, San Francisco, CA 94143, USA.
James MarkowitzNorth Shore Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
Robert BaldassanoChildren's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Anne GriffithsHospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Francisco SylvesterConnecticut Children's Medical Center, Hartford, CT 06106, USA.
David MackChildren's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1 Canada.
Sandra KimNationwide Children's Hospital, Columbus, OH 43228, USA.
Wallace CrandallNationwide Children's Hospital, Columbus, OH 43228, USA.
Jeffrey HyamsConnecticut Children's Medical Center, Hartford, CT 06106, USA.
Curtis HuttenhowerBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Rob KnightBioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA.
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Broad Institute · USUniversity of Colorado Boulder · USHarvard University · USCincinnati Children's Hospital Medical Center · USConnecticut Children's Medical Center · USNationwide Children's Hospital · USBiotechnology Institute · USChildren's Hospital of Eastern Ontario · CAChildren's Hospital of Philadelphia · USEmory University · USGoryeb Children's Hospital · USHospital for Sick Children · CAHoward Hughes Medical Institute · USLong Island Jewish Medical Center · USMayo Clinic in Arizona · USUniversity of California, San Francisco · USUniversity of Toronto · CAWomen & Children's Hospital of Buffalo · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9M
Characterizing the gut microbial ecosystem for diagnosis and therapy in IBDU54DK102557 · NIDDK · BROAD INSTITUTE, INC. · PI HUTTENHOWER, CURTIS, XAVIER, RAMNIK J · 2014 to 2015
$7.7M
Joint Interdisciplinary Training Program in Biostatistics & Computational BiologyT32GM074897 · NIGMS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HUTTENHOWER, CURTIS, LIN, XIHONG · 2005 to 2019
$3.7M
Characterizing the gut microbial ecosystem for diagnosis and therapy in IBDU54DE023798 · NIDCR · BROAD INSTITUTE, INC. · PI HUTTENHOWER, CURTIS, XAVIER, RAMNIK J · 2013 to 2014
$3.0M
Autophagy genes and the microbiome in Crohn's DiseaseR01DK092405 · NIDDK · BROAD INSTITUTE, INC. · PI XAVIER, RAMNIK J · 2012 to 2014
$2.0M
Functional activity and inter-organismal interactions in the human microbiomeR01HG005969 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HUTTENHOWER, CURTIS · 2010 to 2012
$1.3M
NCI NIH HHS R35 CA197449NHGRI NIH HHS R01 HG005969NIDCR NIH HHS U54 DE023798NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK092405NIDDK NIH HHS R01DK092405NIDDK NIH HHS U54 DK102557NIGMS NIH HHS T32 GM074897
6 · The paper itself

Abstract

Inflammatory bowel diseases (IBDs), including Crohn's disease (CD), are genetically linked to host pathways that implicate an underlying role for aberrant immune responses to intestinal microbiota. However, patterns of gut microbiome dysbiosis in IBD patients are inconsistent among published studies. Using samples from multiple gastrointestinal locations collected prior to treatment in new-onset cases, we studied the microbiome in the largest pediatric CD cohort to date. An axis defined by an increased abundance in bacteria which include Enterobacteriaceae, Pasteurellacaea, Veillonellaceae, and Fusobacteriaceae, and decreased abundance in Erysipelotrichales, Bacteroidales, and Clostridiales, correlates strongly with disease status. Microbiome comparison between CD patients with and without antibiotic exposure indicates that antibiotic use amplifies the microbial dysbiosis associated with CD. Comparing the microbial signatures between the ileum, the rectum, and fecal samples indicates that at this early stage of disease, assessing the rectal mucosal-associated microbiome offers unique potential for convenient and early diagnosis of CD.

Indexed as

DysbiosisMicrobiotaAdolescentBacteriaChildChild, PreschoolCohort StudiesCrohn DiseaseGastrointestinal TractHumansMetagenome

Identifiers

PMID24629344
PMCPMC4059512
OpenAlexW2085284704

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.