SynthesisReproductive biology and endocrinology : RB&E2014
Preimplantation genetic screening (PGS) still in search of a clinical application: a systematic review.
Synthesis in Reproductive biology and endocrinology : RB&E, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pregnancy and child developmental outcomes after preimplantation genetic screening: a meta-analytic and systematic review.World journal of pediatrics : WJP · 2018Pooled it
- The impact of patient preselection on reported IVF outcomes.Journal of assisted reproduction and genetics · 2016Pooled it
- Current Applications and Controversies in Preimplantation Genetic Testing for Aneuploidies (PGT-A) in In Vitro Fertilization.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Reproductive ageing-turning back the clock?Irish journal of medical science · 2019Review
- Degree of mosaicism in trophectoderm does not predict pregnancy potential: a corrected analysis of pregnancy outcomes following transfer of mosaic embryos.Reproductive biology and endocrinology : RB&E · 2018Article
- Recent developments in genetics and medically assisted reproduction: from research to clinical applications.European journal of human genetics : EJHG · 2018Review
- A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use.Reproductive biology and endocrinology : RB&E · 2017Article
- Is the hypothesis of preimplantation genetic screening (PGS) still supportable? A review.Journal of ovarian research · 2017Review
- Recurrent pregnancy loss: current perspectives.International journal of women's health · 2017Review
- Recent developments in genetics and medically-assisted reproduction: from research to clinical applicationsHuman reproduction open · 2017Article
- Should preimplantation genetic screening (PGS) be implemented to routine IVF practice?Journal of assisted reproduction and genetics · 2016Article
- Reanalysis of human blastocysts with different molecular genetic screening platforms reveals significant discordance in ploidy status.Journal of assisted reproduction and genetics · 2016Article
- Accuracy of preimplantation genetic screening (PGS) is compromised by degree of mosaicism of human embryos.Reproductive biology and endocrinology : RB&E · 2016Article
- The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.Molecular human reproduction · 2016Review
- Preimplantation genetic screening 2.0: the theory.Molecular human reproduction · 2016Review
- Preimplantation genetic screening- the required RCT that has not yet been carried out.Reproductive biology and endocrinology : RB&E · 2016Article
- Definition by FSH, AMH and embryo numbers of good-, intermediate- and poor-prognosis patients suggests previously unknown IVF outcome-determining factor associated with AMH.Journal of translational medicine · 2016Article
- Aneuploidy analysis in day 7 human blastocysts produced by in vitro fertilization.Reproductive biology and endocrinology : RB&E · 2016Article
- Assessment of clinical application of preimplantation genetic screening on cryopreserved human blastocysts.Reproductive biology and endocrinology : RB&E · 2016Article
- Outcomes of in vitro fertilization with preimplantation genetic diagnosis: an analysis of the United States Assisted Reproductive Technology Surveillance Data, 2011-2012.Fertility and sterility · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Only a few years ago the American Society of Assisted Reproductive Medicine (ASRM), the European Society for Human Reproduction and Embryology (ESHRE) and the British Fertility Society declared preimplantation genetic screening (PGS#1) ineffective in improving in vitro fertilization (IVF) pregnancy rates and in reducing miscarriage rates. A presumably upgraded form of the procedure (PGS#2) has recently been reintroduced, and is here assessed in a systematic review. PGS#2 in comparison to PGS#1 is characterized by: (i) trophectoderm biopsy on day 5/6 embryos in place of day-3 embryo biopsy; and (ii) fluorescence in-situ hybridization (FISH) of limited chromosome numbers is replaced by techniques, allowing aneuploidy assessments of all 24 chromosome pairs. Reviewing the literature, we were unable to identify properly conducted prospective clinical trials in which IVF outcomes were assessed based on "intent to treat". Whether PGS#2 improves IVF outcomes can, therefore, not be determined. Reassessments of data, alleged to support the efficacy of PGS#2, indeed, suggest the opposite. Like with PGS#1, the introduction of PGS#2 into unrestricted IVF practice again appears premature, and threatens to repeat the PGS#1 experience, when thousands of women experienced reductions in IVF pregnancy chances, while expecting improvements. PGS#2 is an unproven and still experimental procedure, which, until evidence suggests otherwise, should only be offered under study conditions, and with appropriate informed consents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.