ArticleMolecular ecology2014
Fine-mapping natural alleles: quantitative complementation to the rescue.
Article in Molecular ecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Genomic Diversity Illuminates the Environmental Adaptation of Drosophila suzukii.Genome biology and evolution · 2024Article
- A Single Nucleotide Variant in the PPARγ-homolog Eip75B Affects Fecundity in Drosophila.Molecular biology and evolution · 2023Article
- Maximum SNP FST Outperforms Full-Window Statistics for Detecting Soft Sweeps in Local Adaptation.Genome biology and evolution · 2022Article
- Genetics as a key to improving crop photosynthesis.Journal of experimental botany · 2022Article
- Review
- The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.PLoS genetics · 2021Article
- Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms.Genetics · 2021Article
- Pollen Number and Ribosome Gene Expression Altered in a Genome-Editing Mutant ofFrontiers in plant science · 2021Article
- Facilitating Complex Trait Analysis via Reduced Complexity Crosses.Trends in genetics : TIG · 2020Review
- Adaptive reduction of male gamete number in the selfing plant Arabidopsis thaliana.Nature communications · 2020Article
- The Genetics of Male Pheromone Preference Difference BetweenG3 (Bethesda, Md.) · 2020Article
- Review
- A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila.Evolution; international journal of organic evolution · 2019Article
- Multiple genetic loci affect place learning and memory performance in Drosophila melanogaster.Genes, brain, and behavior · 2019Article
- Converging phenomics and genomics to study natural variation in plant photosynthetic efficiency.The Plant journal : for cell and molecular biology · 2019Review
- Pleiotropy, constraint, and modularity in the evolution of life histories: insights from genomic analyses.Annals of the New York Academy of Sciences · 2017Review
- A genomic perspective on the generation and maintenance of genetic diversity in herbivorous insects.Annual review of ecology, evolution, and systematics · 2016Article
- Natural Genetic Variation and Candidate Genes for Morphological Traits in Drosophila melanogaster.PloS one · 2016Article
- Mapping QTL Contributing to Variation in Posterior Lobe Morphology between Strains of Drosophila melanogaster.PloS one · 2016Article
- Towards the identification of the loci of adaptive evolution.Methods in ecology and evolution · 2015Review
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Abstract
Mapping the genes responsible for natural variation and divergence is a challenging task. Many studies have mapped genes to genomic regions or generated lists of candidates, but few studies have implicated specific genes with a high standard of evidence. I propose that combining recent advances in genomic engineering with a modified version of the quantitative complementation test will help turn candidate genes into causal genes. By creating loss-of-function mutations in natural strains, and using these mutations to quantitatively fail-to-complement natural alleles, fine mapping should be greatly facilitated. As an example, I propose that the CRISPR/Cas9 system could be combined with the FLP/FRT system to fine-map genes in the numerous systems where inversions have frustrated these efforts.
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