Evidence map›Paper›PMID 24628440›Full record

ArticleHuman gene therapy2014

What is suppression of anti-adeno-associated virus capsid T-cells achieving?

Terence R Flotte, Christian Mueller

Abstract readComment
In one paragraph

Article in Human gene therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Terence R FlotteGene Therapy Center and Department of Pediatrics, University of Massachusetts Medical School , Worcester, MA 01655.
Christian Mueller

Funding

University of Massachusetts Center for Clinical and Translational ScienceUL1TR000161 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2012 to 2015
$11.0M
Preclinical &Phase I/II Trials Of AAV-AAT VectorsR01HL069877 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FLOTTE, TERENCE R. · 2003 to 2013
$3.6M
Nuclease free gene editing approaches to treat alpha-1 antitrypsin diseaseR01DK098252 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FLOTTE, TERENCE R. · 2013 to 2022
$3.0M
NCATS NIH HHS UL1 TR000161NHLBI NIH HHS R01 HL069877NIDDK NIH HHS R01 DK098252
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genetic TherapyDependovirusGenetic VectorsHumansHyperlipoproteinemia Type I

Identifiers

PMID24628440
PMCPMC4442564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.