ArticleAdvanced biomedical research2014
Cytotoxicity of different extracts of arial parts of Ziziphus spina-christi on Hela and MDA-MB-468 tumor cells.
Article in Advanced biomedical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Methanolic Leaves Extract ofInternational journal of molecular sciences · 2025Article
- Exploring the potential of Ziziphus nummularia and luteolin-7-O-glucoside as tubulin inhibitors in cancer therapy and survival.Scientific reports · 2024Article
- Antitumor Activity ofInternational journal of hematology-oncology and stem cell research · 2023Article
- Ethnopharmacology, Biological Evaluation, and Chemical Composition ofAdvances in pharmacological and pharmaceutical sciences · 2022Review
- Article
- In vitro cytotoxicity analysis of Zizyphus spina-christi stem bark extract on human cancer cell lines.Bioinformation · 2020Article
- Emerging CAM Ziziphus nummularia with in vivo sedative-hypnotic, antipyretic and analgesic attributes.3 Biotech · 2016Article
- Evaluation of inhibitory action of novel non β-lactam inhibitor against Klebsiella pneumoniae carbapenemase (KPC-2).PloS one · 2014Article
- The hematopoietic potential of methanolic and aqueous extracts ofAvicenna journal of phytomedicineArticle
- Protective role of Lactobacillus plantarum A7 against irinotecan-induced genotoxicity.Avicenna journal of phytomedicineArticle
- A Completely Polyherbal Conditioning and Antioxidant Shampoo: A Phytochemical Study and Pharmaceutical Evaluation.Journal of pharmacy & bioallied sciencesArticle
- Effect of Iranian Ziziphus honey on growth of some foodborne pathogens.Journal of natural science, biology, and medicineArticle
- The Use ofCase reports in oncologyArticle
- Antiproliferative and Apoptotic Activities of the Medicinal PlantPharmacognosy researchArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been shown that plants from the family Rhamnaceae possess anticancer activity. In this study, we sought to determine if Ziziphus spina-christi, a species from this family, has cytotoxic effect on cancer cell lines. MATERIALS AND
methodsUsing maceration method, different extracts of leaves of Z. spina-christi were prepared. Hexane, chloroform, chloroform-methanol (9:1), methanol-water (7:1) methanol, butanol and water were used for extraction, after preliminary phytochemical analyses were done. The cytotoxic activity of the extracts against Hela and MDA-MB-468 tumor cells was evaluated by MTT assay. Briefly, cells were seeded in microplates and different concentrations of extracts were added. After incubation of cells for 72 h, their viability was evaluated by addition of tetrazolium salt solution. After 3 h medium was aspirated, dimethyl sulfoxide was added and absorbance was determined at 540 nm with an ELISA plate reader. Extracts were considered cytotoxic when more than 50% reduction on cell survival was observed.
resultsHexane, chloroform, chloroform-methanol, butanol, methanol-water and aqueous extracts of Z. spina-christi significantly and concentration-dependently reduced viability of Hela and MAD-MB-468 cells. In the both cell lines, chloroform-methanol extract of Z. spina-christi was more potent than the other extracts.
resultsFrom the finding of this study it can be concluded that Z. spina-christi is a good candidate for further study for new cytotoxic agents.
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