ArticleDiabetes & metabolism journal2014
Statin Discontinuation after Achieving a Target Low Density Lipoprotein Cholesterol Level in Type 2 Diabetic Patients without Cardiovascular Disease: A Randomized Controlled Study.
Article in Diabetes & metabolism journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 2018 Guidelines for the management of dyslipidemia.The Korean journal of internal medicine · 2019Guideline
- Trials evaluating drug discontinuation: a scoping review sub-analysis focusing on outcomes and research questions.BMC medical research methodology · 2025Article
- Postmarketing Reports of Incomplete Dosing-Related Complications with Self-Injected PCSK9 Inhibitors: A Descriptive Study and Disproportionality Analysis.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2024Article
- Cardiovascular Outcomes and Mortality Associated With Discontinuing Statins in Older Patients Receiving Polypharmacy.JAMA network open · 2021Article
- 2018 Guidelines for the Management of Dyslipidemia in Korea.Journal of lipid and atherosclerosis · 2019Review
- Orthodox religious fasting as a medical nutrition therapy for dyslipidemia: where do we stand and how far can we go?European journal of clinical nutrition · 2018Review
- Phenotyping of Korean patients with better-than-expected efficacy of moderate-intensity statins using tensor factorization.PloS one · 2018Article
- Cholesterol variability and the risk of mortality, myocardial infarction, and stroke: a nationwide population-based study.European heart journal · 2017Article
- Statin for the primary prevention of cardiovascular disease in patients with diabetes mellitus.Diabetes & metabolism journal · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study investigated the rate of relapse of dyslipidemia and the factors which could predict relapse following a short-term statin discontinuation after achieving a target low density lipoprotein cholesterol (LDL-C) level in type 2 diabetic patients without cardiovascular disease (CVD).
methodsNinety-nine subjects on rosuvastatin treatment and whose LDL-C level was lower than 100 mg/dL were randomly assigned to discontinue or maintain statin treatment at a 2:1 ratio. The subjects were followed-up after 10 weeks. A relapse of dyslipidemia was defined as a reascent of LDL-C level to greater than 100 mg/dL.
resultsThe statin discontinuation group had a significant rate of relapse compared to the maintenance group (79% vs. 3%, respectively). Pretreatment and baseline lipid levels, their ratios, and hemoglobin A1c level were significantly different between the relapse and nonrelapse groups. The pretreatment and baseline lipid profiles and their ratios were independently associated with relapse. The pretreatment LDL-C level was the most useful parameter for predicting a relapse, with a cutoff of 123 mg/dL. During the follow-up period, no CVD event was noted.
conclusionThe relapse rate of dyslipidemia was high when statins were discontinued in type 2 diabetic patients without CVD. Statin discontinuation should be considered carefully based on the pretreatment lipid profiles of patients.
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