ReviewBiochemia medica2014
Physical activity - an important preanalytical variable.
Review in Biochemia medica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- From Routine Blood Tests to Metabolomics: A Contextual Framework for Interpreting Biomarkers of Training Load, Recovery, and Metabolic Stress in Athletes.Metabolites · 2026Review
- Interpretation of Chemistry, Hematology and Coagulation Laboratory Results in Early-Phase Clinical Pharmacology Trials; a Retrospective Analysis Based on the Placebo Arm of Randomized-Controlled Trials.Clinical and translational science · 2026Article
- The Impact of Endurance Exercise on Routine Laboratory Parameters in Young Trained Individuals.Journal of clinical medicine · 2025Article
- Laboratory medicine and sports: where are we now?Biochemia medica · 2024Review
- Assessing Non-Laboratory Healthcare Professionals' Attitude towards the Importance of Patient Preparation for Laboratory Tests.Healthcare (Basel, Switzerland) · 2024Article
- Total Iron Concentrations in Different Biological Matrices-Influence of Physical Training.Nutrients · 2022Article
- Basal Values of Biochemical and Hematological Parameters in Elite Athletes.International journal of environmental research and public health · 2022Article
- Haematological, Biochemical and Hormonal Biomarkers of Heat Intolerance in Military Personnel.Biology · 2021Article
- Basal myokine levels are associated with quality of life and depressed mood in older adults.Psychophysiology · 2021Article
- A Physically Active Status Affects the Circulating Profile of Cancer-Associated miRNAs.Diagnostics (Basel, Switzerland) · 2021Article
- Vitamin D Status and Its Correlation With Anthropometric and Biochemical Indicators of Cardiometabolic Risk in Serbian Underground Coal Miners in 2016.Frontiers in nutrition · 2021Article
- Influence of chronic training workload on the hematological profile: a pilot study in sedentary people, amateur and professional cyclists.Acta bio-medica : Atenei Parmensis · 2020Article
- Increased level of circulating cell-free mitochondrial DNA due to a single bout of strenuous physical exercise.European journal of applied physiology · 2020Article
- The Influence of Floorball on Hematological Parameters: Consequences in Health Assessment and Antidoping Testing.Journal of sports medicine (Hindawi Publishing Corporation) · 2020Article
- Physical activity and laryngeal cancer.Annals of translational medicine · 2019Review
- Normalization strategies differently affect circulating miRNA profile associated with the training status.Scientific reports · 2019Article
- Errors in the Extra-Analytical Phases of Clinical Chemistry Laboratory Testing.Indian journal of clinical biochemistry : IJCB · 2018Article
- Redox status alterations during the competitive season in élite soccer players: focus on peripheral leukocyte-derived ROS.Internal and emergency medicine · 2017Article
- Role of myokines in cardiovascular diseases and pre-analytical variables affecting their measurements.Annals of translational medicine · 2017Article
- Acutely developing, spurious anaemia without actual blood loss. A paradigmatic case report.Biochemia medica · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concentration of several biochemical and hematological biomarkers is strongly influenced by a number of preanalytical variables. Several lines of evidence attest that short, middle, and long-term exercise, as well as the relative intensity of physical effort (from mild to strenuous), may influence a broad array of laboratory variables. The amount of extracellular release and clearance from blood of most of these biomarkers is markedly influenced by the biological characteristics of the molecule(s), level of training, type, intensity and duration of exercise, and time of recovery after training. It is hence noteworthy that test results that fall outside the conventional reference ranges in athletes not only may reflect the presence of a given disease, but may frequently mirror an adaptation to regular training or changes that have occurred during and/or following strenuous exercise, and which should be clearly acknowledged to prevent misinterpretation of laboratory data. The aim of this narrative review is to provide an update about the most significant changes of some biochemical and hematological biomarkers in response to physical exercise, for appropriate interpretation of these changes in the context of physically active subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.