ArticleElectrolyte & blood pressure : E & BP2013
Severe Hyponatremia Associated with the Use of Angiotensin II Receptor Blocker/thiazide Combinations.
Article in Electrolyte & blood pressure : E & BP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Laboratory medicine in arterial hypertension.Biochemia medica · 2023Review
- Hyponatremia reflects mortality risks other than myocardial damage in acute coronary syndrome.Internal and emergency medicine · 2022Article
- Article
- A case of losartan-induced severe hyponatremia.Journal of pharmacology & pharmacotherapeuticsArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
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Abstract
There are several widely used combinations of angiotensin II receptor blocker (ARB)/thiazide. The complimentary mechanism of action for such anti-hypertensive therapies is that, while ARB inhibits the vasoconstricting and aldosterone-secreting effects of angiotensin II, hydrochlorothiazide affects the renal tubular mechanisms of electrolyte reabsorption and increases excretion of sodium and chloride in the distal tubule, consequently promoting water excretion. In addition, hypokalemia, which may be triggered by a hydrochlorothiazide-induced increase in urinary potassium loss, is resisted by the use of ARB. Hence, the ARB/thiazide combination is safe in terms of potassium imbalance. For these reasons, fixed-dose ARB/thiazide combination anti-hypertensive drugs have been widely used for the treatment of hypertension. However, there have not been many studies done regarding cases where patients under such regimens showed severe hyponatremia, even when the amount of thiazide included was low. Here we report two cases in which severe hyponatremia occurred following treatment with the ARB/thiazide combinations. Upon discontinuation of the regimen, both patients showed recovery from hyponatremia.
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