Evidence map›Paper›PMID 24627656›Full record

ArticlePaediatrics & child health2014

Congenital cytomegalovirus infection in Canada: Active surveillance for cases diagnosed by paediatricians.

Wendy Vaudry, Bonita E Lee, Rhonda J Rosychuk

Open access · bronzeAbstract read
PubMed Full text at PMC
In one paragraph

Article in Paediatrics & child health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. American Cochlear Implant Alliance Position Statement on Newborn Congenital Cytomegalovirus Screening.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Guideline
  2. Article
  3. Article
  4. Article
  5. Observational
  6. AMMI Canada: Response to FAQs about the management of children with congenital cytomegalovirus infection in Canada.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2019
    Article
  7. Article
  8. Article
  9. Maternal Cytomegalovirus (CMV) Serology: The Diagnostic Limitations of CMV IgM and IgG Avidity in Detecting Congenital CMV Infection.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Wendy VaudryDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta;
Bonita E LeeDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta;
Rhonda J RosychukDepartment of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta; ; Women and Children's Health Research Institute, Edmonton, Alberta.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the rate of diagnosis; demographic, clinical and laboratory characteristics; and management of congenital cytomegalovirus (cCMV) cases identified by paediatricians in routine clinical practice in Canada.

methodsNational active monthly surveillance of all clinically practicing general and subspecialty paediatricians in Canada was performed for cCMV from March 1, 2005 to February 28, 2008, through the Canadian Paediatric Surveillance Program.

resultsForty-nine cases of cCMV infection were reported (4.5 per 100,000 births): 40.8% were born before 36 weeks' gestation; 55.1% had a birth weight <2500 g; and 28.6% and 30.6% were below the third percentile for weight and head circumference, respectively. The median maternal age was 23 years, and 18.4% were <20 years of age. Eight mothers (16.3%) were Aboriginal (non-Aboriginal birth prevalence 3.9 per 100,000; Aboriginal birth prevalence 15.8 per 100,000; P<0.005). The most common laboratory abnormality was thrombocytopenia (53.1%). Thirty-three (67.3%) infants exhibited neurological manifestations; ganciclovir therapy was administered to 12 (36.4%) and was not administered to 21 (63.6%) of the infants with neurological manifestations.

conclusionOnly a minority of the expected number of symptomatic cCMV-infected infants were reported in the present study. The majority of these severely affected infants, including those with neurological disease, are not being treated with ganciclovir. The present description of current diagnosis and practice highlights the need for more complete case identification in the population as well as the need for increased awareness of the optimal therapy for symptomatic cCMV.

Indexed as

AboriginalCanadaCongenital infectionCytomegalovirusSurveillance

Identifiers

PMID24627656
PMCPMC3938223
OpenAlexW2125180799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.