ArticleBlood2014
New signaling pathways for hepcidin regulation.
Article in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- An Integrated Systematic Analysis and the Clinical Significance of Hepcidin in Common Malignancies of the Male Genitourinary System.Frontiers in genetics · 2022Article
- TGFβ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology.Investigative ophthalmology & visual science · 2020Article
- Iron Metabolism in Cancer.International journal of molecular sciences · 2018Review
- Whole-body iron transport and metabolism: Mechanistic, multi-scale model to improve treatment of anemia in chronic kidney disease.PLoS computational biology · 2018Article
- [Hepcidin for iron homeostasis and target therapy in ironrelated disorders].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2015Article
- Iron, inflammation and invasion of cancer cells.Clujul medical (1957) · 2015Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this issue of Blood, Mleczko-Sanecka et al used a novel approach based n genome-wide RNA interference knockdown technology to identify the genes involved in the regulation of hepcidin. It showed that hepcidin suppression is linked to the control of mitogen stimulation and nutrient status ia components of well-characterized signaling pathways. This indicates novel links between the control of systemic iron homeostasis and critical liver processes such as regeneration, response to injury, carcinogenesis, and nutrient metabolism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.