ArticleMolecular & cellular proteomics : MCP2014
A second-generation protein-protein interaction network of Helicobacter pylori.
Article in Molecular & cellular proteomics : MCP, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- TheJournal of bacteriology · 2026Article
- Long-read sequencing to detect full-length protein-protein interactions.Scientific reports · 2025Article
- The protein interactome of the citrus Huanglongbing pathogen Candidatus Liberibacter asiaticus.Nature communications · 2023Article
- Article
- Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes.eLife · 2022Article
- Computational Network Inference for Bacterial Interactomics.mSystems · 2022Review
- Computationally Reconstructed Interactome ofInternational journal of molecular sciences · 2021Article
- The Protein Interactome of Glycolysis inProteomes · 2021Article
- Article
- Structural Conservation and Adaptation of the Bacterial Flagella Motor.Biomolecules · 2020Review
- Structural proteomics, electron cryo-microscopy and structural modeling approaches in bacteria-human protein interactions.Medical microbiology and immunology · 2020Review
- Comparative analysis of differential proteome-wide protein-protein interaction network ofBiochemistry and biophysics reports · 2019Article
- Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action.International journal of molecular sciences · 2019Article
- Neglog: Homology-Based Negative Data Sampling Method for Genome-Scale Reconstruction of Human Protein-Protein Interaction Networks.International journal of molecular sciences · 2019Article
- Molecular docking, pharmacophore based virtual screening and molecular dynamics studies towards the identification of potential leads for the management ofRSC advances · 2019Article
- Three SpoA-domain proteins interact in the creation of the flagellar type III secretion system inThe Journal of biological chemistry · 2018Article
- Generating genomic platforms to study Candida albicans pathogenesis.Nucleic acids research · 2018Article
- Iron-sulfur protein maturation in Helicobacter pylori: identifying a Nfu-type cluster carrier protein and its iron-sulfur protein targets.Molecular microbiology · 2018Article
- Proteome Data Improves Protein Function Prediction in the Interactome ofMolecular & cellular proteomics : MCP · 2018Article
- Protein-protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics.Beilstein journal of organic chemistry · 2018Review
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Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
Abstract
Helicobacter pylori infections cause gastric ulcers and play a major role in the development of gastric cancer. In 2001, the first protein interactome was published for this species, revealing over 1500 binary protein interactions resulting from 261 yeast two-hybrid screens. Here we roughly double the number of previously published interactions using an ORFeome-based, proteome-wide yeast two-hybrid screening strategy. We identified a total of 1515 protein-protein interactions, of which 1461 are new. The integration of all the interactions reported in H. pylori results in 3004 unique interactions that connect about 70% of its proteome. Excluding interactions of promiscuous proteins we derived from our new data a core network consisting of 908 interactions. We compared our data set to several other bacterial interactomes and experimentally benchmarked the conservation of interactions using 365 protein pairs (interologs) of E. coli of which one third turned out to be conserved in both species.
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