ArticleCephalalgia : an international journal of headache2014
Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine.
Article in Cephalalgia : an international journal of headache, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
96 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The cerebellum in migraine: a narrative review of anatomical, imaging, and clinical evidence.Frontiers in neurology · 2026Pooled it
- The medial temporal lobe in nociception: a meta-analytic and functional connectivity study.Pain · 2019Pooled it
- Grey matter alterations in migraine: A systematic review and meta-analysis.NeuroImage. Clinical · 2017Pooled it
- Acupuncture at Zuqiaoyin (GB44) Modulates Regional Brain Activity in Migraine Without Aura: A Resting-State Functional Magnetic Resonance Imaging Study.Pain research & management · 2026Trial
- Longitudinal changes in functional connectivity and pain-induced brain activations in patients with migraine: a functional MRI study pre- and post- treatment with Erenumab.The journal of headache and pain · 2022Trial
- The effect of occipital nerve field stimulation on the descending pain pathway in patients with fibromyalgia: a water PET and EEG imaging study.BMC neurology · 2018Trial
- Brain Regional Predictors of Surgical Response Are Dynamically Associated with Post-Surgical Pain Relief in Trigeminal Neuralgia.Brain sciences · 2026Article
- Multiplatform Morphometric Profiling of Whole-Brain, Cerebellar Subregional, and Thalamic Nuclei Alterations in Pediatric Migraine Without Aura.Diagnostics (Basel, Switzerland) · 2026Article
- Assessing the relationships between migraine and driving risks, challenges and coping strategies.Scientific reports · 2026Article
- Alterations of static and dynamic functional connectivity of the nucleus accumbens subregions may be associated with chronic process of migraine: a resting-state fMRI study.The journal of headache and pain · 2026Article
- The Interictal State of Migraine: Understanding the Hidden Burden Between Attacks.Current pain and headache reports · 2026Review
- A Resting State Functional Magnetic Resonance Imaging Study in Migraine Without Aura in Middle and High Altitude Areas.Brain and behavior · 2025Article
- Altered Topology of Brain Structural Network in Patients With Migraine Without Aura: A Structural MRI Study.European journal of pain (London, England) · 2025Article
- Modeling chronic pain interconnections using Bayesian networks: insights from the Qatar Biobank study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024Review
- Altered brainstem-cortex activation and interaction in migraine patients: somatosensory evoked EEG responses with machine learning.The journal of headache and pain · 2024Article
- Disrupted gray matter connectome in vestibular migraine: a combined machine learning and individual-level morphological brain network analysis.The journal of headache and pain · 2024Article
- Structural brain characteristics of epilepsy patients with comorbid migraine without aura.Scientific reports · 2024Article
- Aberrant cerebral blood flow and functional connectivity in patients with vestibular migraine: a resting-state ASL and fMRI study.The journal of headache and pain · 2024Article
- Abnormal functional hubs in migraine patients: a resting-state MRI analysis about voxel-wise degree centrality.Journal of oral & facial pain and headache · 2024Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe objective of this study was to identify brain regions having aberrant pain-induced activation in migraineurs, thereby gaining insight into particular aspects of pain processing that are atypical in migraineurs.
methodsFunctional magnetic resonance imaging assessed whole brain responses to painful heat in 24 adult episodic migraineurs who were at least 48 hours pain free and 27 healthy controls. Regions differentially activated in migraineurs compared to controls were identified. Activation intensities in these regions were correlated with headache frequency, number of migraine years, and time to next migraine attack.
resultsMigraineurs had greater pain-induced activation of lentiform nucleus, fusiform gyrus, subthalamic nucleus, hippocampus, middle cingulate cortex, premotor cortex, somatosensory cortex, and dorsolateral prefrontal cortex, and less activation in precentral gyrus and superior temporal gyrus. There were significant correlations between activation strength and headache frequency for middle cingulate (r = 0.627, p = 0.001), right dorsolateral prefrontal cortex (r = 0.568, p = 0.004), left fusiform gyrus (r = 0.487, p = 0.016), left precentral gyrus (r = 0.415, p = 0.044), and left hippocampus (r = 0.404, p = 0.050) and with number of migraine years for left fusiform gyrus (r = 0.425, p = 0.038). There were no significant correlations between activation strength and time to next migraine attack.
conclusionsThe majority of regions with enhanced pain-induced activation in headache-free migraineurs participate in cognitive aspects of pain perception such as attending to pain and pain memory. Enhanced cognitive pain processing by migraineurs might reflect cerebral hypersensitivity related to high expectations and hypervigilance for pain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.