ArticleThe British journal of psychiatry : the journal of mental science2014
Adversity, cannabis use and psychotic experiences: evidence of cumulative and synergistic effects.
Article in The British journal of psychiatry : the journal of mental science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cumulative exposure to childhood adversity and risk of adult psychosis: a dose-response meta-analysis.Psychological medicine · 2025Pooled it
- Biobehavioral Interactions between Endocannabinoid and Hypothalamicpituitary- adrenal Systems in Psychosis: A Systematic Review.Current neuropharmacology · 2024Pooled it
- A systematic review and meta-analysis of mental health service use in people who report psychotic experiences.Early intervention in psychiatry · 2018Pooled it
- The Relationship Between Trauma Exposure and Nonclinical Psychosis: A Systematic Review and Meta-Analysis.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2026Article
- Childhood Adversities and Psychosis Across Populations: Insights From the 6-Country EU-GEI Study.Schizophrenia bulletin · 2026Article
- How Often, where and by whom are Adverse Experiences Recorded in Clinical Records of Service-Users Under the Care of an Early Intervention in Psychosis (EIP) Service?Community mental health journal · 2026Article
- The impact of childhood trauma and cannabis use on paranoia: a structural equation model approach.Psychological medicine · 2025Observational
- The joint effects of loneliness and interpersonal abuse on suicidal thoughts and behaviors among young adults in higher education in the United States.BMC psychology · 2025Article
- Attenuated mental symptoms in the general population: first data from the observational cross-sectional ATTENTION study in Greece.CNS spectrums · 2025Observational
- Associations between local rates of violence and experiences of psychosis in Trinidad.Frontiers in public health · 2025Article
- Factors associated with the psychosis continuum among homeless people: Comparison between natives and migrants in the SAMENTA study.Journal of migration and health · 2024Article
- The separate and joint effects of recent interpersonal abuse and cannabis use on psychotic experiences: findings from students in higher education in the United States.Social psychiatry and psychiatric epidemiology · 2024Article
- Sex differences in experiences of multiple traumas and mental health problems in the UK Biobank cohort.Social psychiatry and psychiatric epidemiology · 2023Article
- Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study.Psychological medicine · 2023Article
- Psychosocial stress, interpersonal sensitivity, and social withdrawal in clinical high risk for psychosis: a systematic review.Schizophrenia (Heidelberg, Germany) · 2023Review
- [Public mental health from an international perspective: from "shifting the curve" to inclusion of vulnerable populations].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023Review
- Identifying resources used by young people to overcome mental distress in three Latin American cities: a qualitative study.BMJ open · 2022Article
- The Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings From the Multinational EU-GEI Study.Schizophrenia bulletin · 2021Article
- Article
- Mental health consequences of urban air pollution: prospective population-based longitudinal survey.Social psychiatry and psychiatric epidemiology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThere is robust evidence that childhood adversity is associated with an increased risk of psychosis. There is, however, little research on intervening factors that might increase or decrease risk following childhood adversity.
aimsTo investigate main effects of, and synergy between, childhood abuse and life events and cannabis use on odds of psychotic experiences.
methodData on psychotic experiences and childhood abuse, life events and cannabis use were collected from 1680 individuals as part of the South East London Community Health Study (SELCoH), a population-based household survey.
resultsThere was strong evidence that childhood abuse and number of life events combined synergistically to increase odds of psychotic experiences beyond the effects of each individually. There was similar, but weaker, evidence for cannabis use (past year).
conclusionsOur findings are consistent with the hypothesis that childhood abuse creates an enduring vulnerability to psychosis that is realised in the event of exposure to further stressors and risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.