ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2014
The outcome and long-term follow-up of 94 patients with recurrent and refractory Clostridium difficile infection using single to multiple fecal microbiota transplantation via retention enema.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Fecal Microbiota Transplantation (FMT) with Colonoscopy Is Superior to Enema and Nasogastric Tube While Comparable to Capsule for the Treatment of Recurrent Clostridioides difficile Infection: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2021Pooled it
- A Systematic Review of the Efficacy and Safety of Fecal Microbiota Transplant forCanadian journal of gastroenterology & hepatology · 2018Pooled it
- The risk of inflammatory bowel disease flares after fecal microbiota transplantation: Systematic review and meta-analysis.Gut microbes · 2017Pooled it
- Pooled it
- Trial
- A review of engraftment assessments following fecal microbiota transplant.Gut microbes · 2025Review
- The Role of Fecal Microbiota Transplantation in IBD.Microorganisms · 2024Review
- Fecal Microbiota Transplantation: A Prospective Treatment for Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Fecal microbiota transplantation and Clostridioides difficile infection among privately insured patients in the United States.Journal of gastroenterology · 2022Article
- Fecal Microbiota Transplant in Severe and Non-SevereJournal of clinical medicine · 2021Article
- Tandem fecal microbiota transplantation cycles in an allogeneic hematopoietic stem cell transplant recipient targeting carbapenem-resistant Enterobacteriaceae colonization: a case report and literature review.European journal of medical research · 2021Article
- A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group.United European gastroenterology journal · 2021Article
- Review
- Faecal microbiota transplantation for recurrentEClinicalMedicine · 2020Article
- Of men in mice: the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics.Experimental & molecular medicine · 2020Review
- Results from the first English stool bank using faecal microbiota transplant as a medicinal product for the treatment ofEClinicalMedicine · 2020Article
- Long-term durability and safety of fecal microbiota transplantation for recurrent or refractory Clostridioides difficile infection with or without antibiotic exposure.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- The Super-Donor Phenomenon in Fecal Microbiota Transplantation.Frontiers in cellular and infection microbiology · 2019Review
- Efficacy of Routine Fecal Microbiota Transplantation for Treatment of RecurrentInternational journal of microbiology · 2019Article
- Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children: A Joint Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.Journal of pediatric gastroenterology and nutrition · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridium difficile infection (CDI) is one of the most frequent causes of healthcare-associated infections, and its rates are also increasing in the community. The management of CDI has become a major challenge, given growing rates of recurrences and failures with standard antibiotic therapy. Mounting evidence suggests that fecal microbiota transplantation (FMT) may be effective; however, as there is a paucity of data with regard to repeat FMT for primary non-response to this treatment, this study examined the outcome of multiple FMTs for recurrent CDI. Case records were reviewed for 94 patients who underwent FMT via retention enema for recurrent or refractory CDI during the period 2008-2012. Demographic information, treatment data, and clinical resolution rates were examined for single FMT and cumulative resolution was assessed for multiple FMTs in the context of ongoing symptoms. The cumulative clinical resolution following four or more FMTs was 86%. When antibiotic therapy was used between FMTs, the clinical resolution rate increased to 92%. There were no reported adverse events and no patients who were cured with FMT had further episodes of CDI at 6-24 months follow-up. Multiple FMTs administered through enemas is an effective, safe, and simple therapy for the management of recurrent or refractory CDI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.