Evidence map›Paper›PMID 24627132›Full record

SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014

Diagnostic accuracy of serum HE4, CA125 and ROMA in patients with ovarian cancer: a meta-analysis.

Jiwen Wang, Jia Gao, Hongwen Yao, Zongyong Wu, Minjie Wang, Jun Qi

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 4 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 4 syntheses or guidelines pooled it, 122 citations in OpenAlex.

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  11. Diagnostic biomarkers in ovarian cancer: advances beyond CA125 and HE4.Therapeutic advances in medical oncology · 2024
    Review
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  20. Roles of Antimicrobial Peptides in Gynecological Cancers.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jiwen WangZhejiang University, Hangzhou, China.
Jia Gao
Hongwen Yao
Zongyong Wu
Minjie Wang
Jun Qi
Chinese Academy of Medical Sciences & Peking Union Medical College · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CA125, human epididymis secretary protein 4 (HE4) and the Risk of Ovarian Malignancy Algorithm (ROMA) could be used for diagnosing ovarian cancer (OCa). However, it has not been conclusively determined which of these markers yields the best diagnostic accuracy. Therefore, we conducted a meta-analysis to evaluate the diagnostic value of these markers. We systematically searched the PubMed and ScienceDirect databases and identified 32 studies that evaluated the role of CA125, HE4 and ROMA in diagnosing OCa. The bivariate random-effects approach was used to calculate the pooled estimates by considering the heterogeneity of major related parameters such as the menopausal status, International Federation of Gynecology and Obstetrics stages, detection method and blinded design. Three tests yielded similar discriminatory performances in the OCa diagnosis (AUC [95 % CI]-0.89 [0.86-0.92] for HE4; 0.87 [0.84-0.90] for CA125; 0.91 [0.88-0.93] for ROMA). HE4 yielded a higher specificity than CA125 and ROMA (HE4 93.60 [90.00-95.90] >CA125 82.10 [76.60-86.50] and ROMA 82.40 [77.40-86.50]), especially in the premenopausal subgroup (HE4 93.80 [88.40-96.80] >CA125 76.30 [63.30-85.70] and ROMA 85.10 [80.40-88.80]). In contrast, CA125 and ROMA performed significantly better in the postmenopausal subgroup than in the premenopausal subgroup (AUC [95 % CI]-CA125-premenopausal 0.85 [0.82-0.88]<post 0.92 [0.89-0.94]; ROMA-premenopausal 0.86 [0.83-0.89] < post 0.93 [0.90-0.95]). HE4 might be useful for diagnosing OCa due to its high specificity, especially in the premenopausal population. CA125 and ROMA are more suitable for diagnosing OCa in the postmenopausal population. More high-quality RCTs are needed.

Indexed as

CA-125 AntigenFemaleHumansOvarian NeoplasmsProteinsPublication BiasWAP Four-Disulfide Core Domain Protein 2CA-125 AntigenProteinsWAP Four-Disulfide Core Domain Protein 2WFDC2 protein, human

Identifiers

PMID24627132
OpenAlexW2043621331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.