ArticleJournal of lipid research2014
Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families.
Article in Journal of lipid research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Plasma lipid profiling of tissue-specific insulin resistance in human obesity.International journal of obesity (2005) · 2019Trial
- Lipidomic signatures in Colombian adults with metabolic syndrome.Journal of diabetes and metabolic disorders · 2024Article
- Influence of the Human Lipidome on Epicardial Fat Volume in Mexican American Individuals.Frontiers in cardiovascular medicine · 2022Article
- RareJournal of lipid research · 2019Article
- Nonhuman Primates and Translational Research-Cardiovascular Disease.ILAR journal · 2017Review
- Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families.BMC genetics · 2017Article
- Lipidomic analysis enables prediction of clinical outcomes in burn patients.Scientific reports · 2016Article
- Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans.Obesity (Silver Spring, Md.) · 2016Article
- Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease.Lipids in health and disease · 2015Article
- Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes.Genome medicine · 2015Article
- Paradoxical coronary artery disease in humans with hyperalphalipoproteinemia is associated with distinct differences in the high-density lipoprotein phosphosphingolipidome.Journal of clinical lipidologyArticle
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
Abstract
Plasma lipidome is now increasingly recognized as a potentially important marker of chronic diseases, but the exact extent of its contribution to the interindividual phenotypic variability in family studies is unknown. Here, we used the rich data from the ongoing San Antonio Family Heart Study (SAFHS) and developed a novel statistical approach to quantify the independent and additive value of the plasma lipidome in explaining metabolic syndrome (MS) variability in Mexican American families recruited in the SAFHS. Our analytical approach included two preprocessing steps: principal components analysis of the high-resolution plasma lipidomics data and construction of a subject-subject lipidomic similarity matrix. We then used the Sequential Oligogenic Linkage Analysis Routines software to model the complex family relationships, lipidomic similarities, and other important covariates in a variance components framework. Our results suggested that even after accounting for the shared genetic influences, indicators of lipemic status (total serum cholesterol, TGs, and HDL cholesterol), and obesity, the plasma lipidome independently explained 22% of variability in the homeostatic model of assessment-insulin resistance trait and 16% to 22% variability in glucose, insulin, and waist circumference. Our results demonstrate that plasma lipidomic studies can additively contribute to an understanding of the interindividual variability in MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.