Evidence map›Paper›PMID 24627118›Full record

ArticleStroke2014

Extravascular optical coherence tomography: evaluation of carotid atherosclerosis and pravastatin therapy.

Robert T Wicks, Yong Huang, Kang Zhang, Mingtao Zhao, Betty M Tyler, Ian Suk, Lee Hwang, Jacob Ruzevick, George Jallo, Henry Brem and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Robert T Wicks *Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Yong Huang *Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland.
Kang ZhangDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland.
Mingtao ZhaoDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland.
Betty M TylerDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ian SukDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Lee HwangDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jacob RuzevickDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
George JalloDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Henry BremDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Gustavo PradillaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jin U KangDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · US

Funding

OCT-Guided Free-Hand Semi-Automated Microsurgical Tool for Enhanced Retinal SurgeR01EY021540 · NEI · JOHNS HOPKINS UNIVERSITY · PI GEHLBACH, PETER LOUIS, KANG, JIN U · 2011 to 2015
$2.0M
Common-Path OCT for Real Time Imaging in Minimally Invasive NeurosurgeryR21NS063131 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KANG, JIN U · 2009 to 2010
$441k
NEI NIH HHS R01 EY021540NINDS NIH HHS R21 1R21NS063131-01A1NINDS NIH HHS R21 NS063131
6 · The paper itself

Abstract

background and purposeExtravascular optical coherence tomography (OCT), as a noninvasive imaging methodology with micrometer resolution, was evaluated in a murine model of carotid atherosclerosis by way of assessing the efficacy of pravastatin therapy.

methodsAn OCT device was engineered for extravascular plaque imaging. Wild-type mice and apolipoprotein E-deficient (ApoE(-/-)) mice were randomized to 3 treatment groups: (1) wild-type on a diet of standard rodent chow (n=13); (2) ApoE(-/-) on a high-fat, atherosclerotic diet (HFD; n=13); and (3) ApoE(-/-) on a HFD given daily pravastatin (n=13). Mice were anesthetized and the left common carotid was surgically exposed. Three-dimensional (3D; 2 spatial dimensions+time) and 4D (3 spatial dimensions+time) OCT images of the vessel lumen patency were evaluated. After perfusion, in situ OCT imaging was performed for statistical comparison with the in vivo results and final histology.

resultsIntraoperative OCT imaging positively identified carotid plaque in 100% of ApoE(-/-) mice on HFD. ApoE(-/-) mice on HFD had a significantly decreased lumen patency when compared with that in wild-type mice (P<0.001). Pravastatin therapy was found to increase lumen patency significantly in ApoE(-/-) mice on HFD (P<0.01; compared with ApoE(-/-) on HFD). The findings were confirmed with OCT imaging after perfusion and histology.

conclusionsOCT imaging offers the potential for real-time, detailed vessel lumen evaluation, potentially improving surgical accuracy and outcomes during cerebrovascular neurosurgical procedures. Pravastatin significantly increases vessel lumen patency in the ApoE(-/-) mouse on HFD.

Indexed as

AnimalsApolipoproteins ECarotid Artery DiseasesCarotid StenosisDisease Models, AnimalDrug MonitoringHydroxymethylglutaryl-CoA Reductase InhibitorsImaging, Three-DimensionalMiceMice, Inbred C57BLMice, KnockoutPravastatinRandom AllocationTomography, Optical CoherenceApolipoproteins EHydroxymethylglutaryl-CoA Reductase InhibitorsPravastatinatherosclerosisimaging, medicalintracranial aneurysmtomography, optical coherence

Identifiers

PMID24627118
PMCPMC3971651
OpenAlexW2020253863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.