Trial reportJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2014
Contrast-induced acute kidney injury in patients undergoing cardiac resynchronization therapy-incidence and prognostic importance. Sub-analysis of data from randomized TRUST CRT trial.
Trial report in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Zero-contrast cardiac resynchronization therapy device implantation in heart failure patients with renal impairment.Heart rhythm O2 · 2026Article
- Feasibility, safety and outcomes of contrast-free cardiac resynchronisation therapy device implantation: a retrospective cohort comparison.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Article
- Three-dimensional mapping in cardiac implantable electronic device - a feasible and effective alternative to fluoroscopy.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Review
- Clinical risk factors for the prediction of acute kidney injury post cardiac resynchronization therapy in an elderly population.International journal of cardiology. Heart & vasculature · 2020Article
- Reduced Albuminuria and Potassemia Indicate Early Renal Repair Processes after Resynchronization Therapy in Cardiorenal Syndrome Type 2.Cardiology research and practice · 2020Article
- Implantation of BIV ICD with Near Zero Contrast Use in Patients with Advanced Renal Insufficiency Using Three Dimensional Electro-anatomical Mapping.Journal of atrial fibrillation · 2019Article
- Contrast-induced nephropathy after cardiac resynchronization therapy implant impairs the recovery of ejection fraction in responders.ESC heart failure · 2019Article
- End Points for Clinical Trials in Acute Kidney Injury.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Article
- Cardiac resynchronization therapy device implantation guided by electroanatomic mapping system when contrast medium infusion is contraindicated.HeartRhythm case reports · 2016Article
- Non-contrast cardiac resynchronization therapy implantation is feasible in case of renal insufficiency.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2015Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBecause data on contrast-induced acute kidney injury (CI-AKI) in patients undergoing cardiac resynchronization therapy (CRT-D) are scarce, we aimed to assess the incidence, natural course and prognostic importance of this syndrome in CRT recipients.
methodsStudy population consisted of 100 consecutive patients enrolled into the Triple Site Versus Standard Cardiac Resynchronization (TRUST CRT) trial, who were treated with CRT-D. Two patients were excluded up to 3 months after randomization and not analysed further. CI-AKI was defined as a rise in serum creatinine of at least 26.5 μmol/L (0.3 mg/dL) within 48 h after contrast exposure, or at least 50% increase from the baseline value during index hospital stay with CRT-D implantation according to KDIGO Clinical Practice Guideline for Acute Kidney Injury.
resultsAmong 98 subjects of TRUST CRT trial, 10 patients (10.2%) developed CI-AKI after CRT-D implantation. In patients with glomerular filtration rate (GFR) <60 mL/min/1.73 m(2) on admission, the incidence of CI-AKI was almost twofold (15.4%) higher than in subjects with GFR ≥60 (8.3%). CRT-D recipients with CI-AKI had significantly higher mortality rate (50.0%) compared to those without CI-AKI (17.0%) during 30 months of follow-up (logrank p = 0.012). Multivariate Cox regression analysis showed CI-AKI as significant and independent risk factor for death in CRT-D recipients (hazard ratio 5.71; 95% CI 5.16-6.26; p = 0.001).
conclusionsContrast-induced acute kidney injury is a serious and frequent procedural complication of CRT-D implantation with a significant negative influence on long-term survival. The results suggest that clinical evaluation regarding renal function should be considered in CRT-D recipients, both before and after device implantation.
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