Evidence map›Paper›PMID 24626943›Full record

ArticleClinics (Sao Paulo, Brazil)2014

Association of glucocorticoid receptor polymorphisms with clinical and metabolic profiles in polycystic ovary syndrome.

Gustavo A Rosa Maciel, Ricardo P P Moreira, Diogo D G Bugano, Sylvia A Y Hayashida, José A M Marcondes, Larissa G Gomes, Berenice B Mendonça, Tânia A S S Bachega, Edmund C Baracat

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinics (Sao Paulo, Brazil), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Hirsutism, Normal Androgens and Diagnosis of PCOS.Diagnostics (Basel, Switzerland) · 2022
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Gustavo A Rosa MacielFaculdade de Medicina, Universidade de São Paulo, Laboratório de Ginecologia Estrutural e Molecular (LIM/58), São PauloSP, Brazil, Faculdade de Medicina da Universidade de São Paulo, Laboratório de Ginecologia Estrutural e Molecular (LIM/58), Disciplina de Ginecologia, São Paulo/SP, Brazil.
Ricardo P P MoreiraFaculdade de Medicina, Universidade de São Paulo, Laboratório de Hormônios e Genética Molecular (LIM/42), São PauloSP, Brazil, Faculdade de Medicina da Universidade de São Paulo, Laboratório de Hormônios e Genética Molecular (LIM/42), Disciplina de Endocrinologia e Metabologia, São Paulo/SP, Brazil.
Diogo D G BuganoFaculdade de Medicina, Universidade de São Paulo, Departamento de Clínica Médica, São PauloSP, Brazil, Faculdade de Medicina da Universidade de São Paulo, Departamento de Clínica Médica, São Paulo/SP, Brazil.
Sylvia A Y HayashidaFaculdade de Medicina, Universidade de São Paulo, Laboratório de Ginecologia Estrutural e Molecular (LIM/58), São PauloSP, Brazil, Faculdade de Medicina da Universidade de São Paulo, Laboratório de Ginecologia Estrutural e Molecular (LIM/58), Disciplina de Ginecologia, São Paulo/SP, Brazil.
José A M MarcondesFaculdade de Medicina, Universidade de São Paulo, Laboratório de Hormônios e Genética Molecular (LIM/42), São PauloSP, Brazil, Faculdade de Medicina da Universidade de São Paulo, Laboratório de Hormônios e Genética Molecular (LIM/42), Disciplina de Endocrinologia e Metabologia, São Paulo/SP, Brazil.
Larissa G GomesFaculdade de Medicina, Universidade de São Paulo, Laboratório de Hormônios e Genética Molecular (LIM/42), São PauloSP, Brazil, Faculdade de Medicina da Universidade de São Paulo, Laboratório de Hormônios e Genética Molecular (LIM/42), Disciplina de Endocrinologia e Metabologia, São Paulo/SP, Brazil.
Berenice B MendonçaFaculdade de Medicina, Universidade de São Paulo, Laboratório de Hormônios e Genética Molecular (LIM/42), São PauloSP, Brazil, Faculdade de Medicina da Universidade de São Paulo, Laboratório de Hormônios e Genética Molecular (LIM/42), Disciplina de Endocrinologia e Metabologia, São Paulo/SP, Brazil.
Tânia A S S BachegaFaculdade de Medicina, Universidade de São Paulo, Laboratório de Hormônios e Genética Molecular (LIM/42), São PauloSP, Brazil, Faculdade de Medicina da Universidade de São Paulo, Laboratório de Hormônios e Genética Molecular (LIM/42), Disciplina de Endocrinologia e Metabologia, São Paulo/SP, Brazil.
Edmund C BaracatFaculdade de Medicina, Universidade de São Paulo, Laboratório de Ginecologia Estrutural e Molecular (LIM/58), São PauloSP, Brazil, Faculdade de Medicina da Universidade de São Paulo, Laboratório de Ginecologia Estrutural e Molecular (LIM/58), Disciplina de Ginecologia, São Paulo/SP, Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to investigate whether glucocorticoid receptor gene polymorphisms are associated with clinical and metabolic profiles in patients with polycystic ovary syndrome. Polycystic ovary syndrome is a complex endocrine disease that affects 5-8% of women and may be associated with metabolic syndrome, which is a risk factor for cardiovascular disease. Cortisol action and dysregulation account for metabolic syndrome development in the general population. As glucocorticoid receptor gene (NR3C1) polymorphisms regulate cortisol sensitivity, we hypothesized that variants of this gene may be involved in the adverse metabolic profiles of patients with polycystic ovary syndrome.

methodClinical, metabolic and hormonal profiles were evaluated in 97 patients with polycystic ovary syndrome who were diagnosed according to the Rotterdam criteria. The alleles of the glucocorticoid gene were genotyped. Association analyses were performed using the appropriate statistical tests.

resultsObesity and metabolic syndrome were observed in 42.3% and 26.8% of patients, respectively. Body mass index was positively correlated with blood pressure, triglyceride, LDL-c, total cholesterol, glucose and insulin levels as well as HOMA-IR values and inversely correlated with HDL-c and SHBG levels. The BclI and A3669G variants were found in 24.7% and 13.4% of alleles, respectively. BclI carriers presented a lower frequency of insulin resistance compared with wild-type subjects.

conclusionThe BclI variant is associated with a lower frequency of insulin resistance in women with polycystic ovary syndrome. Glucocorticoid gene polymorphism screening during treatment of the syndrome may be useful for identifying subgroups of at-risk patients who would benefit the most from personalized treatment.

Indexed as

AdultAllelesBody Mass IndexCholesterolFemaleFluoroimmunoassayGene FrequencyGenes, bcl-1HumansHypertensionInsulin ResistanceMetabolic SyndromeObesityPolycystic Ovary SyndromePolymerase Chain ReactionPolymorphism, GeneticCholesterolNR3C1 protein, humanReceptors, Glucocorticoid

Identifiers

PMID24626943
PMCPMC3935131
OpenAlexW1992356927

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.