ArticleBrazilian journal of otorhinolaryngology
Influence of estradiol administration on estrogen receptors of nasal mucosa: an experimental study on guinea pigs.
Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Systemic Hormonal Contraceptive Use and Rhinitis Among Adult Women: An All of Us Database Analysis.Laryngoscope investigative otolaryngology · 2025Article
- The effect of surgical menopause after bilateral oophorectomy on hormonal changes, mucociliary clearance, and quality of life.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Article
- Immunity, Sex Hormones, and Environmental Factors as Determinants of COVID-19 Disparity in Women.Frontiers in immunologyReview
- Nasal Obstruction Symptom Evaluation Score Analysis: Exploring Nasal Function in Premenopausal versus Postmenopausal Indian Women.Journal of mid-life healthArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSome clinical trials revealed a correlation between increased serum estrogen and nasal symptoms or inflammatory changes in nasal mucosa. Estrogen receptors tend to be controlled by a negative feedback, to avoid a deleterious stimulus over several body functions while in hyperestrogenic periods. This study proposes a hypothesis where mechanisms regulating expression of estradiol receptors in nasal mucosa are absent in some patients, and their concentration remains steady even in periods of high serum hormonal concentration, potentially leading to local estrogenic symptoms in nasal mucosa. STUDY
designThis was an experimental prospective study.
aimTo determine whether estrogen levels induce the reduction of the number of estrogen receptors in the nasal mucosa.
methodsIn the present study, 30 adult male guinea pigs were subjected to a biopsy of the middle nasal turbinate and received 0.5 mL of estradiol cypionate intraperitoneally for 30 consecutive days. Afterwards, samples from contralateral middle turbinate were obtained. Immunohistochemical analysis of estrogen receptors were performed pre- and post-treatment.
resultsThe post-treatment group showed reduction of receptor expression when compared to the pre-treatment group. (p = 5.2726-5).
conclusionA reduction in the expression of the nasal estrogen receptor was observed after 30 days of estradiol administration.
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