ArticleClinical neuroradiology2015
Outcome prediction in patients after cardiac arrest: a simplified method for determination of gray-white matter ratio in cranial computed tomography.
Article in Clinical neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2025: post-resuscitation care.Intensive care medicine · 2025Guideline
- Imaging for Neuroprognostication After Cardiac Arrest: Systematic Review and Meta-analysis.Neurocritical care · 2020Pooled it
- Prognostic Values of the Gray-to-White Matter Ratio on Brain Computed Tomography Images for Neurological Outcomes after Cardiac Arrest: A Meta-Analysis.BioMed research international · 2020Pooled it
- Efficacy and Safety of Early Treatment with Glibenclamide in Patients with Aneurysmal Subarachnoid Hemorrhage: A Randomized Controlled Trial.Neurocritical care · 2024Trial
- Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study.Scientific reports · 2021Trial
- Neurological prognostication after cardiac arrest: evidence review and institutional protocol proposal.Arquivos de neuro-psiquiatria · 2026Review
- Time-specific comparison of gray-white matter ratio models for predicting outcomes after cardiac arrest: basal ganglia as the leading model.World journal of emergency medicine · 2026Article
- Hounsfield unit and gray-white matter ratio estimates in pediatric normal controls used in studies evaluating head computed tomography.Neuroimage. Reports · 2026Article
- Longitudinal assessment of automated gray-white matter ratio for outcome prediction after cardiac arrest.Critical care (London, England) · 2025Article
- Continuum topological derivative - A novel application tool for segmentation of CT and MRI images.Neuroimage. Reports · 2024Article
- Outcome prediction of cardiac arrest with automatically computed gray-white matter ratio on computed tomography images.Critical care (London, England) · 2024Article
- Prognostic accuracy of head computed tomography for prediction of functional outcome after out-of-hospital cardiac arrest: Rationale and design of the prospective TTM2-CT-substudy.Resuscitation plus · 2022Article
- Gray-White Matter Ratio at the Level of the Basal Ganglia as a Predictor of Neurologic Outcomes in Cardiac Arrest Survivors: A Literature Review.Frontiers in medicine · 2022Review
- Evaluation of the prognosis of acute subdural hematoma according to the density differences between gray and white matter.Frontiers in neurology · 2022Article
- Prognostication of neurologic outcome using gray-white-matter-ratio in comatose patients after cardiac arrest.BMC neurology · 2021Article
- A prognostic scoring system for operated acute epidural hematoma based on gray-white matter ratio.Medicine · 2021Article
- 2020 expert consensus statement on neuro-protection after cardiac arrest in China.Annals of translational medicine · 2021Review
- Predictive Value of Gray-Matter-White-Matter Ratio on Brain Computed Tomography for Delayed Encephalopathy after Acute Carbon Monoxide Poisoning: A Retrospective Cohort Study.BioMed research international · 2021Article
- Article
- How can neurological outcomes be predicted in comatose pediatric patients after out-of-hospital cardiac arrest?Clinical and experimental pediatrics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOut-of-hospital cardiac arrest is a frequent cause of death in Europe. Hypoxic ischemic encephalopathy (HIE) often develops in initial survivors, and the question of treatment limitation arises in severely affected patients. To establish a poor prognosis with a high level of certainty, the use of a combination of prognostic parameters such as neurological examination, somatosensory evoked potentials, and neuron-specific enolase is common practice. A few recent studies suggest that gray-white matter ratio (GWR) determined from cranial computed tomography (CT) scans is an additional reliable predictor of poor prognosis. The standard GWR determination method involves measurements of 16 different regions of interest (ROIs). We tested whether a simplified method to obtain GWR has equivalent reliability for poor outcome prediction. MATERIALS AND
methodsWe retrospectively analyzed 98 patients after cardiac arrest who had been treated with hypothermia. CT scans were obtained within the first 7 days after cardiac arrest. Neurological outcome was determined at intensive care unit discharge. Four different methods to obtain GWR were compared in a receiver-operating characteristic curve analysis with respect to their prognostic value for poor outcome prediction.
resultsThe simplest method using only four ROIs (putamen and internal capsule bilaterally) had the same prognostic value compared with the standard method using 16 ROIs. The simplified GWR predicted poor outcome with a sensitivity of 44 % at 100 % specificity.
conclusionOur results indicate that for poor outcome prediction in survivors of cardiac arrest, a simplified GWR determination is feasible and has the same reliability as the complex standard procedure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.