SynthesisThe journal of nutrition, health & aging2014
Do not resuscitate orders and aging: impact of multimorbidity on the decision-making process.
Synthesis in The journal of nutrition, health & aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Pooled it
- Treatment limitation decision in delirium: a secondary analysis of a prospective observational study.BMC medical ethics · 2025Observational
- Short-term mortality among very elderly cancer patients in the intensive care unit: A retrospective cohort study based on the Medical Information Mart for Intensive Care IV database.Aging medicine (Milton (N.S.W)) · 2024Article
- Exploring adaptive expertise in residency: the (missed) opportunity of uncertainty.Advances in health sciences education : theory and practice · 2024Article
- Practice and Predictors of Do-Not-Resuscitate Orders in a Tertiary-Care Intensive Care Unit in Saudi Arabia.Critical care research and practice · 2024Article
- Care preferences in physician orders for life sustaining treatment in California nursing homes.Journal of the American Geriatrics Society · 2022Article
- Code status documentation at admission in COVID-19 patients: a descriptive cohort study.BMJ open · 2021Article
- Exploring the Impact of Different Types of Do-Not-Resuscitate Consent on End-of-Life Treatments among Patients with Advanced Kidney Disease: An Observational Study.International journal of environmental research and public health · 2021Observational
- Ethical considerations at the end-of-life care.SAGE open medicine · 2021Review
- End-of-Life Care Preferences of Older Patients with Multimorbidity: A Mixed Methods Systematic Review.Journal of clinical medicine · 2020Review
- Conceptualizations of clinical decision-making: a scoping review in geriatric emergency medicine.BMC emergency medicine · 2020Article
- End-of-life care preferences of older patients with multimorbidity: protocol of a mixed-methods systematic review.BMJ open · 2020Article
- Exploration of Medical Trajectories of Stroke Patients Based on Group-Based Trajectory Modeling.International journal of environmental research and public health · 2019Article
- Associations between Mild Cognitive Dysfunction and End-of-Life Outcomes in Patients with Advanced Cancer.Journal of palliative medicine · 2018Article
- Evaluating Postoperative Complications and Outcomes of Orthopedic Fracture Repair in Nonagenarian Patients.Geriatric orthopaedic surgery & rehabilitation · 2018Article
- Social determinants, multimorbidity, and patterns of end-of-life care in older adults dying from cancer.Journal of geriatric oncology · 2017Article
- Do-not-resuscitate orders in cancer patients: a review of literature.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Review
- Do-not-resuscitate orders and related factors among family surrogates of patients in the emergency department.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Early do-not-attempt resuscitation orders and neurological outcomes in older out-of-hospital cardiac arrest patient: A multicenter observational study.Acute medicine & surgeryArticle
- End of Life Care and Do Not Resuscitate Orders: How Much Does Age Influence Decision Making? A Systematic Review and Meta-Analysis.Gerontology & geriatric medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe "Do Not Resuscitate" orders (DNR) are defined as advance medical directives to withhold cardiopulmonary resuscitation during cardiac arrest. Age-related multimorbidity may influence the DNR decision-making process. Our objective was to perform a systematic review and meta-analysis of published data examining the relationship between DNR orders and multimorbidity in older patients.
methodsA systematic Medline and Cochrane literature search limited to human studies published in English and French was conducted on August 2012, with no date limits, using the following Medical Subject Heading terms: "resuscitation orders" OR "do-not-resuscitate" combined with "aged, 80 and over" combined with "comorbidities" OR "chronic diseases".
resultsOf the 65 selected studies, 22 met the selection criteria for inclusion in the qualitative analysis. DNR orders were positively associated with multimorbidity in 21 studies (95%). The meta-analysis included 7 studies with a total of 27,707 participants and 5065 DNR orders. It confirmed that multimorbidity were associated with DNR orders (summary OR = 1.25 [95% CI: 1.19-1.33]). The relationship between DNR orders and multimorbidity differed according to the nature of morbidities; the summary OR for DNR orders was 1.15 (95% CI: 1.07-1.23) for cognitive impairment, OR=2.58 (95% CI: 2.08-3.20) for cancer, OR=1.07 (95% CI: 0.92-1.24) for heart diseases (i.e., coronary heart disease or congestive heart failure), and OR=1.97 (95% CI: 1.61-2.40) for stroke.
conclusionsThis systematic review and meta-analysis showed that DNR orders are positively associated with multimorbidity, and especially with three morbidities, which are cognitive impairment, cancer and stroke.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.