Trial reportEuropean radiology2014
Assessment of portal hypertension and high-risk oesophageal varices with liver and spleen three-dimensional multifrequency MR elastography in liver cirrhosis.
Trial report in European radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Management of acute variceal bleeding: updated APASL guidelines.Hepatology international · 2025Guideline
- Network Meta-Analysis: Noninvasive Imaging Modalities for Identifying Clinically Significant Portal Hypertension.Digestive diseases and sciences · 2022Pooled it
- Diagnostic accuracy of spleen stiffness to evaluate portal hypertension and esophageal varices in chronic liver disease: a systematic review and meta-analysis.European radiology · 2021Pooled it
- Computed tomographyWorld journal of gastroenterology · 2020Pooled it
- Magnetic Resonance Elastography Shear Wave Velocity Correlates with Liver Fibrosis and Hepatic Venous Pressure Gradient in Adults with Advanced Liver Disease.BioMed research international · 2017Trial
- Spleen volume-to-platelet count ratio correlates with portal pressure and is associated with blood loss in laparoscopic non-anatomical hepatectomy.Updates in surgery · 2026Article
- Predicting esophageal varices in cirrhosis: diagnostic utility of MR elastography and dynamic contrast-enhanced MRI.Abdominal radiology (New York) · 2026Article
- Development and evaluation of a predictive model based on multi-frequency magnetic resonance elastography for high-risk esophagogastric varices in patients with cirrhotic portal hypertension.Insights into imaging · 2026Article
- Preliminary quantitative assessment of liver and spleen MR imaging and elastography in clinically significant portal hypertension.Scientific reports · 2026Article
- Intravoxel incoherent motion diffusion-weighted imaging for ruling out high-risk esophageal varices in cirrhosis.Abdominal radiology (New York) · 2025Article
- Superiority of spleen stiffness on two-dimensional magnetic resonance elastography over liver stiffness and serum tests in assessing portal hypertension in chronic liver disease.Quantitative imaging in medicine and surgery · 2024Article
- Postprandial splenic stiffness changes on magnetic resonance elastography in a young healthy population.NMR in biomedicine · 2024Article
- Recent Advances in the Pathogenesis and Clinical Evaluation of Portal Hypertension in Chronic Liver Disease.Gut and liver · 2024Review
- MR Elastography: Practical Questions, From theAJR. American journal of roentgenology · 2024Review
- Evaluation of Spleen Stiffness in Young Healthy Volunteers Using Magnetic Resonance Elastography.Diagnostics (Basel, Switzerland) · 2023Article
- Abdominal MR elastography with multiple driver arrays: performance and repeatability.Abdominal radiology (New York) · 2023Article
- MR elastography outperforms shear wave elastography for the diagnosis of clinically significant portal hypertension.European radiology · 2022Article
- Spleen Stiffness on Magnetic Resonance Elastography for the Detection of Portal Hypertension: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2022Review
- Artificial intelligence in the diagnosis of cirrhosis and portal hypertension.Journal of medical ultrasonics (2001) · 2022Review
- Tomoelastography based on multifrequency MR elastography predicts liver function reserve in patients with hepatocellular carcinoma: a prospective study.Insights into imaging · 2022Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the value of the liver and spleen viscoelastic parameters at multifrequency MR elastography to determine the degree of portal hypertension and presence of high-risk oesophageal varices in patients with cirrhosis.
methodsFrom January to September 2012, 36 consecutive patients with cirrhosis evaluated for transplantation were prospectively included. All patients underwent hepatic venous pressure gradient (HVPG) measurements and endoscopy to assess oesophageal varices. Multifrequency MR elastography was performed within the liver and spleen. The shear, storage and loss moduli were calculated and compared to the HVPG with Spearman coefficients and multiple regressions. Patients with and without severe portal hypertension and high-risk varices were compared with Mann-Whitney tests, logistic regression and ROC analysis.
resultsThe liver storage and loss moduli and the spleen shear, storage and loss moduli correlated with the HVPG. At multiple regression, only the liver and the spleen loss modulus correlated with the HVPG (r = 0.44, p = 0.017, and r = 0.57, p = 0.002, respectively). The spleen loss modulus was the best parameter for identifying patients with severe portal hypertension (p = 0.019, AUROC = 0.81) or high-risk varices (p = 0.042, AUROC = 0.93).
conclusionsThe spleen loss modulus appears to be the best parameter for identifying patients with severe portal hypertension or high-risk varices. KEY POINTS: 1. Noninvasive HVPG assessment can be performed with liver and spleen MR elastography 2. The spleen loss modulus enables the detection of high-risk oesophageal varices 3. The spleen loss modulus enables the detection of severe portal hypertension.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.