Evidence map›Paper›PMID 24626533›Full record

ReviewThe Journal of infectious diseases2014

Pertussis pathogenesis--what we know and what we don't know.

Erik L Hewlett, Drusilla L Burns, Peggy A Cotter, Eric T Harvill, Tod J Merkel, Conrad P Quinn, E Scott Stibitz

Abstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. Article
  3. Genetic diversity ofFrontiers in microbiology · 2025
    Article
  4. Review
  5. Article
  6. Pathogens and global health · 2023
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Bioengineering ofToxins · 2021
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Erik L HewlettDepartments of Medicine and Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia.
Drusilla L Burns
Peggy A Cotter
Eric T Harvill
Tod J Merkel
Conrad P Quinn
E Scott Stibitz

Funding

Baboon Research Resource ProgramP40OD010988 · OD · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI BANKS, RON E · 2012 to 2018
$9.0M
Bordetella cyclase toxin: effects on leukocytes and respiratory epithelial cellsR01AI018000 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HEWLETT, ERIK L · 1985 to 2015
$5.6M
Evolution of the Bordetellae from Commensals to PathogensR01GM083113 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI HARVILL, ERIC T · 2008 to 2011
$2.1M
Function and Secretion of Bordetella Filamentous HemagglutininR01AI094991 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COTTER, PEGGY A · 2012 to 2016
$2.0M
The Microbiota Pathogen CompetitionR01GM113681 · NIGMS · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2015 to 2018
$1.3M
NIAID NIH HHS R01 AI018000NIAID NIH HHS R01 AI094991NIAID NIH HHS R01 AI18000NIGMS NIH HHS R01 GM083113NIGMS NIH HHS R01 GM113681NIH HHS P40 OD010988
6 · The paper itself

Abstract

Pertussis is a worldwide public health threat. Bordetella pertussis produces multiple virulence factors that have been studied individually, and many have recently been found to have additional biological activities. Nevertheless, how they interact to cause the disease pertussis remains unknown. New animal models, particularly the infection of infant baboons with B. pertussis, are enabling longstanding questions about pertussis pathogenesis to be answered and new ones to be asked. Enhancing our understanding of pathogenesis will enable new approaches to the prevention and control of pertussis.

Indexed as

AnimalsAnimals, NewbornBacterial ProteinsBordetella pertussisDisease Models, AnimalPapioVirulenceVirulence FactorsWhooping CoughBacterial ProteinsVirulence FactorsBordetella pertussispathogenesispertussisvirulence factorswhooping cough

Identifiers

PMID24626533
PMCPMC3952676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.