ArticlePloS one2014
How molecular motors work in the crowded environment of living cells: coexistence and efficiency of normal and anomalous transport.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Unraveling the Dynamics of Oxytocin in Hypothalamic Neurons.Traffic (Copenhagen, Denmark) · 2026Article
- Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code.International journal of molecular sciences · 2022Review
- Article
- Collective transient ratchet transport induced by many elastically interacting particles.Scientific reports · 2021Article
- The Impact of Rate Formulations on Stochastic Molecular Motor Dynamics.Scientific reports · 2019Article
- Heterogeneities Shape Passive Intracellular Transport.Biophysical journal · 2019Article
- Crowding-Activity Coupling Effect on Conformational Change of a Semi-Flexible Polymer.Polymers · 2019Article
- Investigation of multiple-dynein transport of melanosomes by non-invasive force measurement using fluctuation unit χ.Scientific reports · 2019Article
- Crowd Control: Effects of Physical Crowding on Cargo Movement in Healthy and Diseased Neurons.Frontiers in cellular neuroscience · 2019Review
- Small-scale displacement fluctuations of vesicles in fibroblasts.Scientific reports · 2018Article
- Label-free Multiscale Transport Imaging of the Living Cell.Biophysical journal · 2018Article
- Retraction of rod-like mitochondria during microtubule-dependent transport.Bioscience reports · 2018Article
- Sensing Magnetic Fields with Magnetosensitive Ion Channels.Sensors (Basel, Switzerland) · 2018Article
- Non-Markovian intracellular transport with sub-diffusion and run-length dependent detachment rate.PloS one · 2018Article
- Cancer drug therapy and stochastic modeling of "nano-motors".International journal of nanomedicine · 2018Article
- A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors.Nature communications · 2017Article
- Run-and-pause dynamics of cytoskeletal motor proteins.Scientific reports · 2016Article
- Molecular machines operating on the nanoscale: from classical to quantum.Beilstein journal of nanotechnology · 2016Review
- Fractal model of anomalous diffusion.European biophysics journal : EBJ · 2015Article
- Simulation tools for particle-based reaction-diffusion dynamics in continuous space.BMC biophysics · 2014Review
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Recent experiments reveal both passive subdiffusion of various nanoparticles and anomalous active transport of such particles by molecular motors in the molecularly crowded environment of living biological cells. Passive and active microrheology reveals that the origin of this anomalous dynamics is due to the viscoelasticity of the intracellular fluid. How do molecular motors perform in such a highly viscous, dissipative environment? Can we explain the observed co-existence of the anomalous transport of relatively large particles of 100 to 500 nm in size by kinesin motors with the normal transport of smaller particles by the same molecular motors? What is the efficiency of molecular motors in the anomalous transport regime? Here we answer these seemingly conflicting questions and consistently explain experimental findings in a generalization of the well-known continuous diffusion model for molecular motors with two conformational states in which viscoelastic effects are included.
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