ArticlePloS one2014
Responses to elevated c-di-GMP levels in mutualistic and pathogenic plant-interacting bacteria.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 83 citations in OpenAlex.
- TolC Is Required for a Mixed-Linkage β-Glucan (MLG) Biosynthesis: Engineering Bacteria for MLG Overproduction.Microbial biotechnology · 2026Article
- Evolutionary mechanisms underlying bacterial adaptation to the plant environment.FEMS microbiology reviews · 2026Review
- Cyclic-di-GMP interferes with DNA-MucR-DNA bridging to derepress genes targeted by the xenogeneic silencer MucR.Nucleic acids research · 2025Article
- Cyclic di-GMP Modulation of Quorum Sensing and Its Impact on Type VI Secretion System Function inMicroorganisms · 2025Article
- Cyclic Diguanylate in the Wild: Roles During Plant and Animal Colonization.Annual review of microbiology · 2024Review
- Article
- Quantification of Mixed-Linkage β-Glucan (MLG) in Bacteria.Methods in molecular biology (Clifton, N.J.) · 2024Article
- TheMicrobiology (Reading, England) · 2023Article
- Bioinformatics characterization of BcsA-like orphan proteins suggest they form a novel family of pseudomonad cyclic-β-glucan synthases.PloS one · 2023Article
- FleQ, FleN and c-di-GMP coordinately regulate cellulose production inFrontiers in molecular biosciences · 2023Article
- Impact of c-di-GMP on the Extracellular Proteome ofBiology · 2022Article
- Article
- CsrD regulates amylovoran biosynthesis and virulence in Erwinia amylovora in a novel cyclic-di-GMP dependent manner.Molecular plant pathology · 2022Article
- Regulation of extracellular matrix components by AmrZ is mediated by c-di-GMP in Pseudomonas ogarae F113.Scientific reports · 2022Article
- The enhanced expression of genes encoding diguanylate cyclases under cold stress contributes to the adhesion and biofilm formation ofFrontiers in nutrition · 2022Article
- Article
- Motility, Adhesion and c-di-GMP Influence the Endophytic Colonization of Rice byMicroorganisms · 2021Article
- Beyond the Wall: Exopolysaccharides in the Biofilm Lifestyle of Pathogenic and Beneficial Plant-AssociatedMicroorganisms · 2021Review
- CdgC, a Cyclic-di-GMP Diguanylate Cyclase ofFrontiers in plant science · 2021Article
- The RsmA RNA-Binding Proteins inFrontiers in plant science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite a recent burst of research, knowledge on c-di-GMP signaling pathways remains largely fragmentary and molecular mechanisms of regulation and even c-di-GMP targets are yet unknown for most bacteria. Besides genomics or bioinformatics, accompanying alternative approaches are necessary to reveal c-di-GMP regulation in bacteria with complex lifestyles. We have approached this study by artificially altering the c-di-GMP economy of diverse pathogenic and mutualistic plant-interacting bacteria and examining the effects on the interaction with their respective host plants. Phytopathogenic Pseudomonas and symbiotic Rhizobium strains with enhanced levels of intracellular c-di-GMP displayed common free-living responses: reduction of motility, increased production of extracellular polysaccharides and enhanced biofilm formation. Regarding the interaction with the host plants, P. savastanoi pv. savastanoi cells containing high c-di-GMP levels formed larger knots on olive plants which, however, displayed reduced necrosis. In contrast, development of disease symptoms in P. syringae-tomato or P. syringae-bean interactions did not seem significantly affected by high c-di-GMP. On the other hand, increasing c-di-GMP levels in symbiotic R. etli and R. leguminosarum strains favoured the early stages of the interaction since enhanced adhesion to plant roots, but decreased symbiotic efficiency as plant growth and nitrogen contents were reduced. Our results remark the importance of c-di-GMP economy for plant-interacting bacteria and show the usefulness of our approach to reveal particular stages during plant-bacteria associations which are sensitive to changes in c-di-GMP levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.