ArticlePloS one2014
Quantification of acute vocal fold epithelial surface damage with increasing time and magnitude doses of vibration exposure.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Mouse Vocal Fold Permeability In Vivo: Effects of Novel Low-Tech Injury and Instillation Methods.The Laryngoscope · 2026Article
- Discovering the Effects of Superior-Surface Vocal Fold Lesions via Fluid-Structure Interaction Analysis.Bioengineering (Basel, Switzerland) · 2025Article
- Comparative Three-Dimensional Fine Structures of the Rabbit Vocal Fold Using Correlative Light and Electron Microscopy.The Laryngoscope · 2025Article
- Biophysical aspects of mechanotransduction in cells and their physiological/biological implications in vocal fold vibration: a narrative review.Frontiers in cell and developmental biology · 2025Review
- Effects of Short-term Electronic(e)-Cigarette Aerosol Exposure in the Mouse Larynx.The Laryngoscope · 2024Article
- The Effect of Oxidative Stress on the Human Voice.International journal of molecular sciences · 2024Review
- Collision Pressure and Dissipated Power Dose in a Self-Oscillating Silicone Vocal Fold Model With a Posterior Glottal Opening.Journal of speech, language, and hearing research : JSLHR · 2022Article
- Recurring exposure to low humidity induces transcriptional and protein level changes in the vocal folds of rabbits.Scientific reports · 2021Article
- Hydrogel-Supported, Engineered Model of Vocal Fold Epithelium.ACS biomaterials science & engineering · 2021Article
- Restoration Strategies Following Short-Term Vocal Exertion in Healthy Young Adults.Journal of speech, language, and hearing research : JSLHR · 2021Article
- Vocal fold dynamics in a synthetic self-oscillating model: Contact pressure and dissipated-energy dose.The Journal of the Acoustical Society of America · 2021Article
- Short-term whole body cigarette smoke exposure induces regional differences in cellular response in the mouse larynx.Toxicology reports · 2021Article
- Protein Substrate Alters Cell Physiology in Primary Culture of Vocal Fold Epithelial Cells.Cells, tissues, organs · 2021Article
- RNA sequencing identifies transcriptional changes in the rabbit larynx in response to low humidity challenge.BMC genomics · 2020Article
- Continuous Rate Infusion of Ketamine Hydrochloride and Dexmedetomidine for Maintenance of Anesthesia during Laryngotracheal Surgery in New Zealand White Rabbits (Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Ovine Vocal Fold Tissue Fatigue Response to Accumulated, Large-Amplitude Vibration Exposure at Phonatory Frequencies.Journal of speech, language, and hearing research : JSLHR · 2019Article
- Toward Development of a Vocal Fold Contact Pressure Probe: Sensor Characterization and Validation Using Synthetic Vocal Fold Models.Applied sciences (Basel, Switzerland) · 2019Article
- Prolonged phonation impairs the integrity and barrier function of porcine vocal fold epithelium: a preliminary study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Article
- High-Performance Agent-Based Modeling Applied to Vocal Fold Inflammation and Repair.Frontiers in physiology · 2018Article
- In vivo measurement of vocal fold surface resistance.The Laryngoscope · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Because the vocal folds undergo repeated trauma during continuous cycles of vibration, the epithelium is routinely susceptible to damage during phonation. Excessive and prolonged vibration exposure is considered a significant predisposing factor in the development of vocal fold pathology. The purpose of the present study was to quantify the extent of epithelial surface damage following increased time and magnitude doses of vibration exposure using an in vivo rabbit phonation model. Forty-five New Zealand white breeder rabbits were randomized to nine groups and received varying phonation time-doses (30, 60, or 120 minutes) and magnitude-doses (control, modal intensity phonation, or raised intensity phonation) of vibration exposure. Scanning electron microscopy and transmission electron microscopy was used to quantify the degree of epithelial surface damage. Results revealed a significant reduction in microprojection density, microprojection height, and depth of the epithelial surface with increasing time and phonation magnitudes doses, signifying increased epithelial surface damage risk with excessive and prolonged vibration exposure. Destruction to the epithelial cell surface may provide significant insight into the disruption of cell function following prolonged vibration exposure. One important goal achieved in the present study was the quantification of epithelial surface damage using objective imaging criteria. These data provide an important foundation for future studies of long-term tissue recovery from excessive and prolonged vibration exposure.
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Registered trials
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