Evidence map›Paper›PMID 24626053›Full record

SynthesisPloS one2014

Etiologies and resistance profiles of bacterial community-acquired pneumonia in Cambodian and neighboring countries' health care settings: a systematic review (1995 to 2012).

Sophie Goyet, Erika Vlieghe, Varun Kumar, Steven Newell, Catrin E Moore, Rachel Bousfield, Heng C Leang, Sokheng Chuop, Phe Thong, Blandine Rammaert and 6 more

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. High prevalence and associated factors ofJournal of preventive medicine and hygiene · 2025
    Article
  2. Article
  3. Detection ofWellcome open research · 2023
    Article
  4. Article
  5. Klebsiella pneumoniae Lower Respiratory Tract Infection in a South African Birth Cohort: a Longitudinal Study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
  6. Article
  7. Article
  8. Observational
  9. Pneumonia in the tropics.Respirology (Carlton, Vic.) · 2018
    Review
  10. Article
  11. Recent Developments in Pediatric Community-Acquired Pneumonia.Current infectious disease reports · 2016
    Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 5 countries.

Sophie GoyetEpidemiology unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
Erika VliegheInstitute of Tropical Medicine, Antwerp, Belgium.
Varun KumarAngkor Hospital for Children, Siem Reap, Cambodia.
Steven NewellNaval Medical Research Unit2, Phnom Penh, Cambodia.
Catrin E MooreAngkor Hospital for Children, Siem Reap, Cambodia; Wellcome Trust Major Overseas Programme, Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford University, Oxford, United Kingdom.
Rachel BousfieldAngkor Hospital for Children, Siem Reap, Cambodia; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford University, Oxford, United Kingdom.
Heng C LeangNational Institute of Public Health, Phnom Penh, Cambodia.
Sokheng ChuopNational Institute of Public Health, Phnom Penh, Cambodia.
Phe ThongSihanouk Hospital Center of HOPE, Phnom Penh, Cambodia.
Blandine RammaertHopital Necker-Enfants malades service des Maladies Infectieuses et Tropicales, APHP, Paris, France.
Sopheak HemEpidemiology unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
Johan van GriensvenInstitute of Tropical Medicine, Antwerp, Belgium; Sihanouk Hospital Center of HOPE, Phnom Penh, Cambodia.
Agus RachmatNaval Medical Research Unit2, Phnom Penh, Cambodia.
Thomas FassierUniversity of Health Sciences, Faculty of Medicine, Phnom Penh, Cambodia.
Kruy LimSihanouk Hospital Center of HOPE, Phnom Penh, Cambodia.
Arnaud TarantolaEpidemiology unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
Institut Pasteur du Cambodge · KHCambodia-Oxford Medical Research Unit · KHInstituut voor Tropische Geneeskunde · BENational Institute of Public Health · KHSihanouk Hospital Center of HOPE · KHAngkor Hospital for Children · KHChurchill Hospital · GBHôpital Necker-Enfants Malades · FRUniversity of Health Science · KHUniversity of Oxford · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

objectivesCommunity-acquired pneumonia (CAP) is one of the most important causes of morbidity and mortality worldwide. Etiological data for Cambodia is scarce. We aimed to describe the main etiological agents causing CAP, and their resistance patterns in Cambodia and the greater Mekong region.

methodsA review of bacterial etiologies of CAP and antimicrobial resistance in Cambodia and neighboring countries was conducted via: (1) a systematic review of published literature in all NCBI databases using Pubmed, Google scholar, EMBASE, the World Health Organization and the Cambodian Ministry of Health libraries; (2) a review of unpublished data from Cambodia provided by national and international stakeholders working at different tiers of the healthcare system.

resultsTwenty three articles and five data sources reported etiologies for 5919 CAP patients diagnosed between May 1995 and December 2012, including 1421 (24.0%), 3571 (60.3%) and 927 (15.7%) from Cambodia, Thailand and Vietnam, respectively. Streptococcus pneumoniae and Haemophilus influenzae were the most common pathogens ranking among the five most prevalent in 12 and 10 studies, respectively. Gram-negative bacteria such as Burkholderia pseudomallei and Klebsiella pneumoniae were also frequently diagnosed, particularly in bacteremic CAP in Thai adults and Cambodian children. In Thailand and Vietnam, Mycoplasma pneumoniae and Chlamydia pneumoniae were frequently identified in settings using indirect laboratory testing.

conclusionsBased on this analysis, CAP data in Cambodia seems to present etiological and resistance profiles comparable to those of neighboring countries. Findings have been shared with the national authorities upon the revision of the national therapeutic guidelines and were disseminated using a specially created website.

Indexed as

Drug Resistance, BacterialBurkholderia pseudomalleiCambodiaChlamydophila pneumoniaeCommunity-Acquired InfectionsHaemophilus influenzaeHumansKlebsiella pneumoniaeMycoplasma pneumoniaePneumonia, BacterialPrevalenceStreptococcus pneumoniae

Identifiers

PMID24626053
PMCPMC3953073
OpenAlexW1969861782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.