ArticleCell death & disease2014
URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription.
Article in Cell death & disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Comparative analysis between highFrontiers in oncology · 2023Article
- Molecular and immunological mechanisms of clonal evolution in multiple myeloma.Frontiers in immunology · 2023Review
- Silence of URI in gastric cancer cells promotes cisplatin-induced DNA damage and apoptosis.American journal of cancer research · 2023Article
- ALCAM regulates multiple myeloma chemoresistant side population.Cell death & disease · 2022Article
- Macrophage Rmp Ameliorates Myocardial Infarction by Modulating Macrophage Polarization in Mice.Oxidative medicine and cellular longevity · 2022Article
- Review
- RPB5-mediating protein promotes the progression of non-small cell lung cancer by regulating the proliferation and invasion.Journal of thoracic disease · 2021Article
- The Expression of MicroRNA-598 Inhibits Ovarian Cancer Cell Proliferation and Metastasis by Targeting URI.Molecular therapy oncolytics · 2019Article
- RMP/URI inhibits both intrinsic and extrinsic apoptosis through different signaling pathways.International journal of biological sciences · 2019Article
- RMP promotes the proliferation and radioresistance of esophageal carcinoma.Journal of Cancer · 2019Article
- NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple Myeloma.International journal of molecular sciences · 2018Review
- URI knockdown induces autophagic flux in gastric cancer cells.American journal of cancer research · 2018Article
- RMP promotes epithelial-mesenchymal transition through NF-κB/CSN2/Snail pathway in hepatocellular carcinoma.Oncotarget · 2017Article
- R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.Nature communications · 2017Article
- Regulation of STAT3 and NF-κB activations by S-nitrosylation in multiple myeloma.Free radical biology & medicine · 2017Article
- URI promotes the migration and invasion of human cervical cancer cells potentially via upregulation of vimentin expression.American journal of translational research · 2017Article
- Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice.Scientific reports · 2016Article
- Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1.Oncotarget · 2016Article
- URI prevents potassium dichromate-induced oxidative stress and cell death in gastric cancer cells.American journal of translational research · 2016Article
- URI promotes gastric cancer cell motility, survival, and resistance to adriamycin in vitro.American journal of cancer research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unconventional prefoldin RPB5 interactor (URI), which acts as an oncoprotein in solid tumors, is associated with RNA polymerase II subunit 5. However, its impact on multiple myeloma (MM) has not been determined. We demonstrate here that URI is overexpressed in MM compared with plasma cells derived from healthy volunteers. Side population (SP) cells sorted from MM cells showed a much higher level of URI than non-SP cells. Using lentivirus-delivered shRNA, we established stable URI knockdown MM cell lines. URI inhibition significantly attenuated the proliferation of MM cells and decreased colony formation compared with the control cells. Tumor growth assays in NOD/SCID mice further confirmed the promotion role of URI during MM development in vivo. Furthermore, URI knockdown markedly reduced the abundance of SP in MM cell lines and enhanced the chemotherapeutic sensitivity of MM towards bortezomib. Mechanically, URI appears to be critically involved in modulating STAT3 activity through regulating interleukin (IL)-6 transcription via interaction with NFκBp65. In conclusion, URI may have an important role in the development of MM and chemotherapeutic resistance through activating the IL-6/STAT3 pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.