ArticleGenome biology and evolution2014
Phylogenomics and the dynamic genome evolution of the genus Streptococcus.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed.
- Acquisition of a novel restriction modification system regulates genetic flux and gene expression in the hypervirulent and globally disseminated CC17 lineage of group B Streptococcus.Nucleic acids research · 2026Article
- Polymethyl methacrylate microplastics affect oral microbiota diversity andFrontiers in microbiology · 2026Article
- An Unusual Case ofInfection and drug resistance · 2026Article
- CRISPR spacer profiling and prophage mining reveal diverse bacteriophages associated withJournal of oral microbiology · 2026Article
- A zinc-free alternative ribosomal protein RpsN.2 confers survival advantage to group A streptococcus during Zn scarcity.Infection and immunity · 2025Article
- Pan-genome analysis of Morganella morganii reveals niche-specific selection of functional traits: friend or foe?Archives of microbiology · 2025Article
- Re-evaluation of boundaries ofInternational journal of systematic and evolutionary microbiology · 2025Article
- Streptococcus abundance and oral site tropism in humans and non-human primates reflects host and lifestyle differences.NPJ biofilms and microbiomes · 2025Article
- Genomic analysis of conjugative and chromosomally integrated mobile genetic elements in oral streptococci.Applied and environmental microbiology · 2024Article
- Article
- Hybrid sequence-based analysis reveals the distribution of bacterial species and genes in the oral microbiome at a high resolution.Biochemistry and biophysics reports · 2024Article
- Genome analysis of Streptococcus spp. isolates from animals in pre-antibiotic era with respect to antibiotic susceptibility and virulence gene profiles.Veterinary research · 2024Article
- Unveiling the complexity of early childhood caries:Journal of oral microbiology · 2024Review
- Characterization of MdpS: an in-depth analysis of a MUC5B-degrading protease fromFrontiers in microbiology · 2024Article
- Pyrosequencing analysis of bacterial community changes in dental unit waterlines after chlorogenic acid treatment.Frontiers in cellular and infection microbiology · 2024Article
- Dynamic interactions between Candida albicans and different streptococcal species in a multispecies oral biofilm.MicrobiologyOpen · 2023Article
- The applications of CRISPR/Cas-mediated genome editing in genetic hearing loss.Cell & bioscience · 2023Review
- Microbial contamination and composition of oral samples subjected to clinical whole genome sequencing.Frontiers in genetics · 2023Article
- Oral Commensal Streptococci: Gatekeepers of the Oral Cavity.Journal of bacteriology · 2022Review
- The findings of glucosyltransferase enzymes derived from oral streptococci.The Japanese dental science review · 2022Review
23 more citing papers are in PubMed but not listed here.
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9 authors.
Funding
Abstract
The genus Streptococcus comprises important pathogens that have a severe impact on human health and are responsible for substantial economic losses to agriculture. Here, we utilize 46 Streptococcus genome sequences (44 species), including eight species sequenced here, to provide the first genomic level insight into the evolutionary history and genetic basis underlying the functional diversity of all major groups of this genus. Gene gain/loss analysis revealed a dynamic pattern of genome evolution characterized by an initial period of gene gain followed by a period of loss, as the major groups within the genus diversified. This was followed by a period of genome expansion associated with the origins of the present extant species. The pattern is concordant with an emerging view that genomes evolve through a dynamic process of expansion and streamlining. A large proportion of the pan-genome has experienced lateral gene transfer (LGT) with causative factors, such as relatedness and shared environment, operating over different evolutionary scales. Multiple gene ontology terms were significantly enriched for each group, and mapping terms onto the phylogeny showed that those corresponding to genes born on branches leading to the major groups represented approximately one-fifth of those enriched. Furthermore, despite the extensive LGT, several biochemical characteristics have been retained since group formation, suggesting genomic cohesiveness through time, and that these characteristics may be fundamental to each group. For example, proteolysis: mitis group; urea metabolism: salivarius group; carbohydrate metabolism: pyogenic group; and transcription regulation: bovis group.
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